Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain

Elevated levels of acrolein, an α,β-unsaturated aldehyde are detected in the brain of patients with Parkinson’s disease (PD). In the present study, the neuroprotective effect of baicalein (a phenolic flavonoid in the dried root of Scutellaria baicalensis Georgi) on acrolein-induced neurodegeneration...

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Veröffentlicht in:	Molecular neurobiology 2018, Vol.55 (1), p.130-137
Hauptverfasser:	Zhao, Wei-Zhong, Wang, Hsiang-Tsui, Huang, Hui-Ju, Lo, Yu-Li, Lin, Anya Maan-Yuh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein Acrolein - toxicity Animals Antioxidants - pharmacology Apoptosis Astrocytes Biomarkers Biomedical and Life Sciences Biomedicine Brain Caspase Caspase-1 Caspase-3 Cathepsin B Cell Biology Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Flavanones - pharmacology Glial fibrillary acidic protein Heme Inflammasomes Inflammation Kinases Lipid peroxidation Lysine Male Microglia Movement disorders Necroptosis Neostriatum Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Neurotoxicity Oxidative stress Oxygenase Parkinson's disease Peroxidation Phenols Protein kinase Proteins Rats Rats, Sprague-Dawley Rodents Substantia Nigra - drug effects Substantia Nigra - metabolism
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