Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers
In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have b...
Gespeichert in:
| Veröffentlicht in: | AIChE journal 2018-03, Vol.64 (3), p.835-859 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 859 |
|---|---|
| container_issue | 3 |
| container_start_page | 835 |
| container_title | AIChE journal |
| container_volume | 64 |
| creator | Fan, Jiangli Wang, Suzhen Sun, Wen Guo, Shigang Kang, Yao Du, Jianjun Peng, Xiaojun |
| description | In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano‐DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real‐time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in‐depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 64: 835–859, 2018 |
| doi_str_mv | 10.1002/aic.15976 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2000648217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2000648217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3346-ebf98a10e8173d288af863084d2b640b38d3bd2a3a464146a10a69d4ddddf0f93</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EEqUw8A8sMTGk9VccZ6wqPipVYoGByXJsp7hK7WInVPn3GMLKLac7Pfe-uheAW4wWGCGyVE4vcFlX_AzMcMmqoqxReQ5mCCFc5AW-BFcp7fNEKkFm4H3le6eV1zZCE4cdNLZzXzaOMI2pt4cEG5WsgcFD50PcKe809MoHrWJ0NiZ4cv0HbLshRJu09T3so8pq6RpctKpL9uavz8Hb48Pr-rnYvjxt1qttoSllvLBNWwuFkRW4ooYIoVrBKRLMkIYz1FBhaGOIoopxhhnPqOK1YSZXi9qazsHdpHuM4XOwqZf7MESfLSXJX3MmSFaeg_uJ0jGkFG0rj9EdVBwlRvInOZmTk7_JZXY5sSfX2fF_UK426-niG94mcKE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2000648217</pqid></control><display><type>article</type><title>Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fan, Jiangli ; Wang, Suzhen ; Sun, Wen ; Guo, Shigang ; Kang, Yao ; Du, Jianjun ; Peng, Xiaojun</creator><creatorcontrib>Fan, Jiangli ; Wang, Suzhen ; Sun, Wen ; Guo, Shigang ; Kang, Yao ; Du, Jianjun ; Peng, Xiaojun</creatorcontrib><description>In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano‐DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real‐time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in‐depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 64: 835–859, 2018</description><identifier>ISSN: 0001-1541</identifier><identifier>EISSN: 1547-5905</identifier><identifier>DOI: 10.1002/aic.15976</identifier><language>eng</language><publisher>New York: American Institute of Chemical Engineers</publisher><subject>Antitumor agents ; Cancer ; chemotherapeutic drug ; Chemotherapy ; Drug delivery ; Drug delivery systems ; Drugs ; Fluorescence ; fluorescence imaging ; fluorescence tracing ; Fluorescent dyes ; Fluorescent indicators ; Hydroxyapatite ; inorganic nanocarriers ; Iron oxides ; Macromolecules ; Metals ; Quantum dots ; Rare earth elements ; Signal processing ; Silica ; Silicon dioxide ; targeted drug delivery ; Tracers</subject><ispartof>AIChE journal, 2018-03, Vol.64 (3), p.835-859</ispartof><rights>2017 American Institute of Chemical Engineers</rights><rights>2018 American Institute of Chemical Engineers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3346-ebf98a10e8173d288af863084d2b640b38d3bd2a3a464146a10a69d4ddddf0f93</citedby><cites>FETCH-LOGICAL-c3346-ebf98a10e8173d288af863084d2b640b38d3bd2a3a464146a10a69d4ddddf0f93</cites><orcidid>0000-0003-4962-5186 ; 0000-0002-8806-322X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Faic.15976$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Faic.15976$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Fan, Jiangli</creatorcontrib><creatorcontrib>Wang, Suzhen</creatorcontrib><creatorcontrib>Sun, Wen</creatorcontrib><creatorcontrib>Guo, Shigang</creatorcontrib><creatorcontrib>Kang, Yao</creatorcontrib><creatorcontrib>Du, Jianjun</creatorcontrib><creatorcontrib>Peng, Xiaojun</creatorcontrib><title>Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers</title><title>AIChE journal</title><description>In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano‐DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real‐time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in‐depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 64: 835–859, 2018</description><subject>Antitumor agents</subject><subject>Cancer</subject><subject>chemotherapeutic drug</subject><subject>Chemotherapy</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Fluorescence</subject><subject>fluorescence imaging</subject><subject>fluorescence tracing</subject><subject>Fluorescent dyes</subject><subject>Fluorescent indicators</subject><subject>Hydroxyapatite</subject><subject>inorganic nanocarriers</subject><subject>Iron oxides</subject><subject>Macromolecules</subject><subject>Metals</subject><subject>Quantum dots</subject><subject>Rare earth elements</subject><subject>Signal processing</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>targeted drug delivery</subject><subject>Tracers</subject><issn>0001-1541</issn><issn>1547-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PwzAQhi0EEqUw8A8sMTGk9VccZ6wqPipVYoGByXJsp7hK7WInVPn3GMLKLac7Pfe-uheAW4wWGCGyVE4vcFlX_AzMcMmqoqxReQ5mCCFc5AW-BFcp7fNEKkFm4H3le6eV1zZCE4cdNLZzXzaOMI2pt4cEG5WsgcFD50PcKe809MoHrWJ0NiZ4cv0HbLshRJu09T3so8pq6RpctKpL9uavz8Hb48Pr-rnYvjxt1qttoSllvLBNWwuFkRW4ooYIoVrBKRLMkIYz1FBhaGOIoopxhhnPqOK1YSZXi9qazsHdpHuM4XOwqZf7MESfLSXJX3MmSFaeg_uJ0jGkFG0rj9EdVBwlRvInOZmTk7_JZXY5sSfX2fF_UK426-niG94mcKE</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Fan, Jiangli</creator><creator>Wang, Suzhen</creator><creator>Sun, Wen</creator><creator>Guo, Shigang</creator><creator>Kang, Yao</creator><creator>Du, Jianjun</creator><creator>Peng, Xiaojun</creator><general>American Institute of Chemical Engineers</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U5</scope><scope>8FD</scope><scope>C1K</scope><scope>L7M</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0003-4962-5186</orcidid><orcidid>https://orcid.org/0000-0002-8806-322X</orcidid></search><sort><creationdate>201803</creationdate><title>Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers</title><author>Fan, Jiangli ; Wang, Suzhen ; Sun, Wen ; Guo, Shigang ; Kang, Yao ; Du, Jianjun ; Peng, Xiaojun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3346-ebf98a10e8173d288af863084d2b640b38d3bd2a3a464146a10a69d4ddddf0f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antitumor agents</topic><topic>Cancer</topic><topic>chemotherapeutic drug</topic><topic>Chemotherapy</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Fluorescence</topic><topic>fluorescence imaging</topic><topic>fluorescence tracing</topic><topic>Fluorescent dyes</topic><topic>Fluorescent indicators</topic><topic>Hydroxyapatite</topic><topic>inorganic nanocarriers</topic><topic>Iron oxides</topic><topic>Macromolecules</topic><topic>Metals</topic><topic>Quantum dots</topic><topic>Rare earth elements</topic><topic>Signal processing</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>targeted drug delivery</topic><topic>Tracers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Jiangli</creatorcontrib><creatorcontrib>Wang, Suzhen</creatorcontrib><creatorcontrib>Sun, Wen</creatorcontrib><creatorcontrib>Guo, Shigang</creatorcontrib><creatorcontrib>Kang, Yao</creatorcontrib><creatorcontrib>Du, Jianjun</creatorcontrib><creatorcontrib>Peng, Xiaojun</creatorcontrib><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Environment Abstracts</collection><jtitle>AIChE journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Jiangli</au><au>Wang, Suzhen</au><au>Sun, Wen</au><au>Guo, Shigang</au><au>Kang, Yao</au><au>Du, Jianjun</au><au>Peng, Xiaojun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers</atitle><jtitle>AIChE journal</jtitle><date>2018-03</date><risdate>2018</risdate><volume>64</volume><issue>3</issue><spage>835</spage><epage>859</epage><pages>835-859</pages><issn>0001-1541</issn><eissn>1547-5905</eissn><abstract>In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano‐DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real‐time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in‐depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 64: 835–859, 2018</abstract><cop>New York</cop><pub>American Institute of Chemical Engineers</pub><doi>10.1002/aic.15976</doi><tpages>25</tpages><orcidid>https://orcid.org/0000-0003-4962-5186</orcidid><orcidid>https://orcid.org/0000-0002-8806-322X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-1541 |
| ispartof | AIChE journal, 2018-03, Vol.64 (3), p.835-859 |
| issn | 0001-1541 1547-5905 |
| language | eng |
| recordid | cdi_proquest_journals_2000648217 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Antitumor agents Cancer chemotherapeutic drug Chemotherapy Drug delivery Drug delivery systems Drugs Fluorescence fluorescence imaging fluorescence tracing Fluorescent dyes Fluorescent indicators Hydroxyapatite inorganic nanocarriers Iron oxides Macromolecules Metals Quantum dots Rare earth elements Signal processing Silica Silicon dioxide targeted drug delivery Tracers |
| title | Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T22%3A27%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anticancer%20drug%20delivery%20systems%20based%20on%20inorganic%20nanocarriers%20with%20fluorescent%20tracers&rft.jtitle=AIChE%20journal&rft.au=Fan,%20Jiangli&rft.date=2018-03&rft.volume=64&rft.issue=3&rft.spage=835&rft.epage=859&rft.pages=835-859&rft.issn=0001-1541&rft.eissn=1547-5905&rft_id=info:doi/10.1002/aic.15976&rft_dat=%3Cproquest_cross%3E2000648217%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2000648217&rft_id=info:pmid/&rfr_iscdi=true |