Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy
Summary Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis. Objectives To investigate the feasibility of delivering PDT using a portable light‐emitting diode device. Methods A prototype diod...
Gespeichert in:
| Veröffentlicht in: | British journal of dermatology (1951) 2006-04, Vol.154 (4), p.747-750 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 750 |
|---|---|
| container_issue | 4 |
| container_start_page | 747 |
| container_title | British journal of dermatology (1951) |
| container_volume | 154 |
| creator | Moseley, H. Allen, J.W. Ibbotson, S. Lesar, A. McNeill, A. Camacho-Lopez, M.A. Samuel, I.D.W. Sibbett, W. Ferguson, J. |
| description | Summary
Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis.
Objectives To investigate the feasibility of delivering PDT using a portable light‐emitting diode device.
Methods A prototype diode array, comprising 37 AlGaInP diodes cast in epoxy with a diffuser, and driven by a battery pack, was designed and constructed. A pilot study was carried out in five patients with histologically proven Bowen's disease who were referred for PDT with 5‐aminolaevulinic acid. They were all treated in the hospital‐based dermatology PDT suite such that each received the same level of supervision as patients receiving PDT with nonambulatory light sources. Patients recorded pain levels. In accordance with our usual practice, patients received two treatments at a 4‐week interval.
Results Four of five patients were clear at follow‐up (range 6–13 months, median 9). Pain was classified as none or mild in 80% of treatments and moderate in the remainder.
Conclusions There are many potential benefits of ambulatory PDT, including the possibility of a much higher patient throughput, and allowing effective treatment at home. This pilot study provides early promising data of the safety and efficacy of this approach. |
| doi_str_mv | 10.1111/j.1365-2133.2006.07145.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_200055950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1024891761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4135-f2d4f929b1e0d3052cb5ed03edcc45b1c5f1f3cba957f2bfd0f60630f57ebc0a3</originalsourceid><addsrcrecordid>eNptkU1PwzAMhiMEgjH4C6hC4tjiNHVKkTjAYIPxJRAIblGaJtDRtSXtYP33tGzABV9syc9rW68JcSh4tI39iUcZR9enjHk-APcgpAF68xXS-22skh4AhC5EnG2QzaqaAFAGCOtkg3Jk_MD3e-TueBrPMlkXtnHK16IukiaX01Q59au2smwOHenk-tNRRa50WTtp7iQ6Sz-0TfOXfxVbZM3IrNLby9wnj8Ozh8G5e3U7uhgcX7kqoAxd4yeBifwophqS9ixfxagTYDpRKsCYKjTUMBXLCEPjxyYBw4EzMBjqWIFkfbK7mFva4n2mq1pMipnN25WitQQQI4QW2llCs3iqE1HadCptI34MaIG9JSArJTNjZa7S6o8L8QBDDFruaMF9pplu_voguoeIieh8F53v3XYuvh8i5uJkfNpVrd5d6NOq1vNfvbRvgocsRPF0MxJ4Pr5-vr-7FEP2BVJdjkM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200055950</pqid></control><display><type>article</type><title>Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Moseley, H. ; Allen, J.W. ; Ibbotson, S. ; Lesar, A. ; McNeill, A. ; Camacho-Lopez, M.A. ; Samuel, I.D.W. ; Sibbett, W. ; Ferguson, J.</creator><creatorcontrib>Moseley, H. ; Allen, J.W. ; Ibbotson, S. ; Lesar, A. ; McNeill, A. ; Camacho-Lopez, M.A. ; Samuel, I.D.W. ; Sibbett, W. ; Ferguson, J.</creatorcontrib><description>Summary
Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis.
Objectives To investigate the feasibility of delivering PDT using a portable light‐emitting diode device.
Methods A prototype diode array, comprising 37 AlGaInP diodes cast in epoxy with a diffuser, and driven by a battery pack, was designed and constructed. A pilot study was carried out in five patients with histologically proven Bowen's disease who were referred for PDT with 5‐aminolaevulinic acid. They were all treated in the hospital‐based dermatology PDT suite such that each received the same level of supervision as patients receiving PDT with nonambulatory light sources. Patients recorded pain levels. In accordance with our usual practice, patients received two treatments at a 4‐week interval.
Results Four of five patients were clear at follow‐up (range 6–13 months, median 9). Pain was classified as none or mild in 80% of treatments and moderate in the remainder.
Conclusions There are many potential benefits of ambulatory PDT, including the possibility of a much higher patient throughput, and allowing effective treatment at home. This pilot study provides early promising data of the safety and efficacy of this approach.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2006.07145.x</identifier><identifier>PMID: 16536822</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>5-aminolaevulinic acid ; Ambulatory Care - methods ; Biological and medical sciences ; Bowen's disease ; Bowen's Disease - drug therapy ; Dermatology ; Diseases of the skin. Cosmetics ; Equipment Design ; Feasibility Studies ; Humans ; light-emitting diode ; Lighting - instrumentation ; Medical sciences ; Pain - etiology ; Photochemotherapy - adverse effects ; Photochemotherapy - instrumentation ; Photochemotherapy - methods ; photodynamic therapy ; Pilot Projects ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Skin Neoplasms - drug therapy ; Treatment Outcome ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>British journal of dermatology (1951), 2006-04, Vol.154 (4), p.747-750</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Apr 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4135-f2d4f929b1e0d3052cb5ed03edcc45b1c5f1f3cba957f2bfd0f60630f57ebc0a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2006.07145.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2006.07145.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17585754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16536822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moseley, H.</creatorcontrib><creatorcontrib>Allen, J.W.</creatorcontrib><creatorcontrib>Ibbotson, S.</creatorcontrib><creatorcontrib>Lesar, A.</creatorcontrib><creatorcontrib>McNeill, A.</creatorcontrib><creatorcontrib>Camacho-Lopez, M.A.</creatorcontrib><creatorcontrib>Samuel, I.D.W.</creatorcontrib><creatorcontrib>Sibbett, W.</creatorcontrib><creatorcontrib>Ferguson, J.</creatorcontrib><title>Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis.
Objectives To investigate the feasibility of delivering PDT using a portable light‐emitting diode device.
Methods A prototype diode array, comprising 37 AlGaInP diodes cast in epoxy with a diffuser, and driven by a battery pack, was designed and constructed. A pilot study was carried out in five patients with histologically proven Bowen's disease who were referred for PDT with 5‐aminolaevulinic acid. They were all treated in the hospital‐based dermatology PDT suite such that each received the same level of supervision as patients receiving PDT with nonambulatory light sources. Patients recorded pain levels. In accordance with our usual practice, patients received two treatments at a 4‐week interval.
Results Four of five patients were clear at follow‐up (range 6–13 months, median 9). Pain was classified as none or mild in 80% of treatments and moderate in the remainder.
Conclusions There are many potential benefits of ambulatory PDT, including the possibility of a much higher patient throughput, and allowing effective treatment at home. This pilot study provides early promising data of the safety and efficacy of this approach.</description><subject>5-aminolaevulinic acid</subject><subject>Ambulatory Care - methods</subject><subject>Biological and medical sciences</subject><subject>Bowen's disease</subject><subject>Bowen's Disease - drug therapy</subject><subject>Dermatology</subject><subject>Diseases of the skin. Cosmetics</subject><subject>Equipment Design</subject><subject>Feasibility Studies</subject><subject>Humans</subject><subject>light-emitting diode</subject><subject>Lighting - instrumentation</subject><subject>Medical sciences</subject><subject>Pain - etiology</subject><subject>Photochemotherapy - adverse effects</subject><subject>Photochemotherapy - instrumentation</subject><subject>Photochemotherapy - methods</subject><subject>photodynamic therapy</subject><subject>Pilot Projects</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Treatment Outcome</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1PwzAMhiMEgjH4C6hC4tjiNHVKkTjAYIPxJRAIblGaJtDRtSXtYP33tGzABV9syc9rW68JcSh4tI39iUcZR9enjHk-APcgpAF68xXS-22skh4AhC5EnG2QzaqaAFAGCOtkg3Jk_MD3e-TueBrPMlkXtnHK16IukiaX01Q59au2smwOHenk-tNRRa50WTtp7iQ6Sz-0TfOXfxVbZM3IrNLby9wnj8Ozh8G5e3U7uhgcX7kqoAxd4yeBifwophqS9ixfxagTYDpRKsCYKjTUMBXLCEPjxyYBw4EzMBjqWIFkfbK7mFva4n2mq1pMipnN25WitQQQI4QW2llCs3iqE1HadCptI34MaIG9JSArJTNjZa7S6o8L8QBDDFruaMF9pplu_voguoeIieh8F53v3XYuvh8i5uJkfNpVrd5d6NOq1vNfvbRvgocsRPF0MxJ4Pr5-vr-7FEP2BVJdjkM</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Moseley, H.</creator><creator>Allen, J.W.</creator><creator>Ibbotson, S.</creator><creator>Lesar, A.</creator><creator>McNeill, A.</creator><creator>Camacho-Lopez, M.A.</creator><creator>Samuel, I.D.W.</creator><creator>Sibbett, W.</creator><creator>Ferguson, J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>200604</creationdate><title>Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy</title><author>Moseley, H. ; Allen, J.W. ; Ibbotson, S. ; Lesar, A. ; McNeill, A. ; Camacho-Lopez, M.A. ; Samuel, I.D.W. ; Sibbett, W. ; Ferguson, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4135-f2d4f929b1e0d3052cb5ed03edcc45b1c5f1f3cba957f2bfd0f60630f57ebc0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>5-aminolaevulinic acid</topic><topic>Ambulatory Care - methods</topic><topic>Biological and medical sciences</topic><topic>Bowen's disease</topic><topic>Bowen's Disease - drug therapy</topic><topic>Dermatology</topic><topic>Diseases of the skin. Cosmetics</topic><topic>Equipment Design</topic><topic>Feasibility Studies</topic><topic>Humans</topic><topic>light-emitting diode</topic><topic>Lighting - instrumentation</topic><topic>Medical sciences</topic><topic>Pain - etiology</topic><topic>Photochemotherapy - adverse effects</topic><topic>Photochemotherapy - instrumentation</topic><topic>Photochemotherapy - methods</topic><topic>photodynamic therapy</topic><topic>Pilot Projects</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Treatment Outcome</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moseley, H.</creatorcontrib><creatorcontrib>Allen, J.W.</creatorcontrib><creatorcontrib>Ibbotson, S.</creatorcontrib><creatorcontrib>Lesar, A.</creatorcontrib><creatorcontrib>McNeill, A.</creatorcontrib><creatorcontrib>Camacho-Lopez, M.A.</creatorcontrib><creatorcontrib>Samuel, I.D.W.</creatorcontrib><creatorcontrib>Sibbett, W.</creatorcontrib><creatorcontrib>Ferguson, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moseley, H.</au><au>Allen, J.W.</au><au>Ibbotson, S.</au><au>Lesar, A.</au><au>McNeill, A.</au><au>Camacho-Lopez, M.A.</au><au>Samuel, I.D.W.</au><au>Sibbett, W.</au><au>Ferguson, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2006-04</date><risdate>2006</risdate><volume>154</volume><issue>4</issue><spage>747</spage><epage>750</epage><pages>747-750</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis.
Objectives To investigate the feasibility of delivering PDT using a portable light‐emitting diode device.
Methods A prototype diode array, comprising 37 AlGaInP diodes cast in epoxy with a diffuser, and driven by a battery pack, was designed and constructed. A pilot study was carried out in five patients with histologically proven Bowen's disease who were referred for PDT with 5‐aminolaevulinic acid. They were all treated in the hospital‐based dermatology PDT suite such that each received the same level of supervision as patients receiving PDT with nonambulatory light sources. Patients recorded pain levels. In accordance with our usual practice, patients received two treatments at a 4‐week interval.
Results Four of five patients were clear at follow‐up (range 6–13 months, median 9). Pain was classified as none or mild in 80% of treatments and moderate in the remainder.
Conclusions There are many potential benefits of ambulatory PDT, including the possibility of a much higher patient throughput, and allowing effective treatment at home. This pilot study provides early promising data of the safety and efficacy of this approach.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16536822</pmid><doi>10.1111/j.1365-2133.2006.07145.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2006-04, Vol.154 (4), p.747-750 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_journals_200055950 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | 5-aminolaevulinic acid Ambulatory Care - methods Biological and medical sciences Bowen's disease Bowen's Disease - drug therapy Dermatology Diseases of the skin. Cosmetics Equipment Design Feasibility Studies Humans light-emitting diode Lighting - instrumentation Medical sciences Pain - etiology Photochemotherapy - adverse effects Photochemotherapy - instrumentation Photochemotherapy - methods photodynamic therapy Pilot Projects Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Skin Neoplasms - drug therapy Treatment Outcome Tumors of the skin and soft tissue. Premalignant lesions |
| title | Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T20%3A15%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ambulatory%20photodynamic%20therapy:%20a%20new%20concept%20in%20delivering%20photodynamic%20therapy&rft.jtitle=British%20journal%20of%20dermatology%20(1951)&rft.au=Moseley,%20H.&rft.date=2006-04&rft.volume=154&rft.issue=4&rft.spage=747&rft.epage=750&rft.pages=747-750&rft.issn=0007-0963&rft.eissn=1365-2133&rft.coden=BJDEAZ&rft_id=info:doi/10.1111/j.1365-2133.2006.07145.x&rft_dat=%3Cproquest_pubme%3E1024891761%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=200055950&rft_id=info:pmid/16536822&rfr_iscdi=true |