A bio-inspired approach to proline-derived 2,4-disubstituted oxazoles

A convenient four-step approach to the synthesis of ( )-4-alkyl-2-(pyrrolidin-2-yl)oxazoles starting from -Boc-proline inspired by naturally occurring oxazole-containing peptidomimetics is described. The key step is the cyclization of 1-Boc- -(1-oxoalkan-2-yl)pyrrolidine-2-carboxamides – aldehyde in...

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Veröffentlicht in:	Heterocyclic communications 2018-02, Vol.24 (1), p.11-17
Hauptverfasser:	Slobodyanyuk, Evgeniy Y., Artamonov, Oleksiy S., Kulik, Irene B., Rusanov, Eduard, Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical synthesis conformational restriction heteroaliphatic lead-oriented synthesis Oxazole oxazoles peptidomimetics Proline synthesis
Online-Zugang:	Volltext
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