Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats
Free radicals play a pivotal role in many pathophysiological states, such as myopathies. Atorvastatin is a known cholesterol-lowering agent with many pleiotropic actions including antioxidant properties. However, the impact of atorvastatin on myocardial oxidative stress is not well known. The aim of...
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| Veröffentlicht in: | Comparative clinical pathology 2018-05, Vol.27 (3), p.691-697 |
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| description | Free radicals play a pivotal role in many pathophysiological states, such as myopathies. Atorvastatin is a known cholesterol-lowering agent with many pleiotropic actions including antioxidant properties. However, the impact of atorvastatin on myocardial oxidative stress is not well known. The aim of this study was to evaluate the role of atorvastatin in improving diabetes-induced oxidative stress in the myocardium. Male Wistar rats weighing 20–25 g were randomly divided into four groups as normal, normal-treated, diabetes, and diabetes-treated. Induction of diabetes was performed by a single dose of streptozotocin (40 mg/kg, i.v.). Treated animals received atorvastatin for 8 weeks orally (40 mg/kg/day). After 8 weeks, animals were sacrificed and myocardial tissues were removed. Then, nitrate, glutathione (GSH), and malondialdehyde (MDA) contents as well as enzymatic activities of catalase (CAT) and superoxide dismutase (SOD) in the myocardial tissues were determined. Diabetes-induced oxidative stress by increasing nitrous free radicals (nitrate) (
p
≤ 0.001) and MDA content (
p
≤ 0.001), but had no significant effects on SOD, CAT, and GSH activities. Atorvastatin treatment in diabetic animals decreased free radical-induced damages by decreasing nitrate and MDA content and increasing GSH and SOD activities compared to control non-diabetic animals. Uncontrolled hyperglycemia induces oxidative burden in myocardium. Treatment by atorvastatin decreases oxidative and nitrosative stress in the myocardium of diabetic animals. |
| doi_str_mv | 10.1007/s00580-018-2652-2 |
| format | Article |
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p
≤ 0.001) and MDA content (
p
≤ 0.001), but had no significant effects on SOD, CAT, and GSH activities. Atorvastatin treatment in diabetic animals decreased free radical-induced damages by decreasing nitrate and MDA content and increasing GSH and SOD activities compared to control non-diabetic animals. Uncontrolled hyperglycemia induces oxidative burden in myocardium. Treatment by atorvastatin decreases oxidative and nitrosative stress in the myocardium of diabetic animals.</description><identifier>ISSN: 1618-5641</identifier><identifier>EISSN: 1618-565X</identifier><identifier>DOI: 10.1007/s00580-018-2652-2</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Antioxidants ; Atorvastatin ; Catalase ; Cholesterol ; Diabetes ; Diabetes mellitus ; Free radicals ; Glutathione ; Hematology ; Hyperglycemia ; Malondialdehyde ; Medicine ; Medicine & Public Health ; Myocardium ; Nitrates ; Oncology ; Original Article ; Oxidative stress ; Pathology ; Rodents ; Streptozocin ; Superoxide dismutase</subject><ispartof>Comparative clinical pathology, 2018-05, Vol.27 (3), p.691-697</ispartof><rights>Springer-Verlag London Ltd., part of Springer Nature 2018</rights><rights>Comparative Clinical Pathology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2312-4aef4729469a2ffbeac2b105ad9b4121ea1bad09b787723f8d82c191b4383d1b3</citedby><cites>FETCH-LOGICAL-c2312-4aef4729469a2ffbeac2b105ad9b4121ea1bad09b787723f8d82c191b4383d1b3</cites><orcidid>0000-0002-8656-1444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00580-018-2652-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00580-018-2652-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Yaribeygi, Habib</creatorcontrib><creatorcontrib>Faghihi, Nastaran</creatorcontrib><creatorcontrib>Mohammadi, Mohammad Taghi</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><title>Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats</title><title>Comparative clinical pathology</title><addtitle>Comp Clin Pathol</addtitle><description>Free radicals play a pivotal role in many pathophysiological states, such as myopathies. Atorvastatin is a known cholesterol-lowering agent with many pleiotropic actions including antioxidant properties. However, the impact of atorvastatin on myocardial oxidative stress is not well known. The aim of this study was to evaluate the role of atorvastatin in improving diabetes-induced oxidative stress in the myocardium. Male Wistar rats weighing 20–25 g were randomly divided into four groups as normal, normal-treated, diabetes, and diabetes-treated. Induction of diabetes was performed by a single dose of streptozotocin (40 mg/kg, i.v.). Treated animals received atorvastatin for 8 weeks orally (40 mg/kg/day). After 8 weeks, animals were sacrificed and myocardial tissues were removed. Then, nitrate, glutathione (GSH), and malondialdehyde (MDA) contents as well as enzymatic activities of catalase (CAT) and superoxide dismutase (SOD) in the myocardial tissues were determined. Diabetes-induced oxidative stress by increasing nitrous free radicals (nitrate) (
p
≤ 0.001) and MDA content (
p
≤ 0.001), but had no significant effects on SOD, CAT, and GSH activities. Atorvastatin treatment in diabetic animals decreased free radical-induced damages by decreasing nitrate and MDA content and increasing GSH and SOD activities compared to control non-diabetic animals. Uncontrolled hyperglycemia induces oxidative burden in myocardium. Treatment by atorvastatin decreases oxidative and nitrosative stress in the myocardium of diabetic animals.</description><subject>Antioxidants</subject><subject>Atorvastatin</subject><subject>Catalase</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Free radicals</subject><subject>Glutathione</subject><subject>Hematology</subject><subject>Hyperglycemia</subject><subject>Malondialdehyde</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocardium</subject><subject>Nitrates</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Pathology</subject><subject>Rodents</subject><subject>Streptozocin</subject><subject>Superoxide dismutase</subject><issn>1618-5641</issn><issn>1618-565X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLAzEUhYMoWKs_wF3A9WhuMq8spVQrFNwougs3k0SmtJOapMX-e1NGxI2r--Cccy8fIdfAboGx5i4yVrWsYNAWvK54wU_IBOo8VXX1fvrbl3BOLmJcMQZVK8SEvM2ds12K1DuKyYc9xoSpH6gf6ObgOwymxzX1X73J672lOBg69Cn4OM4xBRsjzY4s1Db1HQ2Y4iU5c7iO9uqnTsnrw_xltiiWz49Ps_tl0XEBvCjRurLhsqwlcue0xY5rYBUaqUvgYBE0GiZ10zYNF641Le9Agi5FKwxoMSU3Y-42-M-djUmt_C4M-aQCKWXJhQSeVTCquvx3DNapbeg3GA4KmDryUyM_lfmpIz919PDRE7N2-LDhT_K_pm-ZcHPC</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Yaribeygi, Habib</creator><creator>Faghihi, Nastaran</creator><creator>Mohammadi, Mohammad Taghi</creator><creator>Sahebkar, Amirhossein</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid></search><sort><creationdate>20180501</creationdate><title>Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats</title><author>Yaribeygi, Habib ; Faghihi, Nastaran ; Mohammadi, Mohammad Taghi ; Sahebkar, Amirhossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2312-4aef4729469a2ffbeac2b105ad9b4121ea1bad09b787723f8d82c191b4383d1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antioxidants</topic><topic>Atorvastatin</topic><topic>Catalase</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Free radicals</topic><topic>Glutathione</topic><topic>Hematology</topic><topic>Hyperglycemia</topic><topic>Malondialdehyde</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocardium</topic><topic>Nitrates</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Pathology</topic><topic>Rodents</topic><topic>Streptozocin</topic><topic>Superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaribeygi, Habib</creatorcontrib><creatorcontrib>Faghihi, Nastaran</creatorcontrib><creatorcontrib>Mohammadi, Mohammad Taghi</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Comparative clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaribeygi, Habib</au><au>Faghihi, Nastaran</au><au>Mohammadi, Mohammad Taghi</au><au>Sahebkar, Amirhossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats</atitle><jtitle>Comparative clinical pathology</jtitle><stitle>Comp Clin Pathol</stitle><date>2018-05-01</date><risdate>2018</risdate><volume>27</volume><issue>3</issue><spage>691</spage><epage>697</epage><pages>691-697</pages><issn>1618-5641</issn><eissn>1618-565X</eissn><abstract>Free radicals play a pivotal role in many pathophysiological states, such as myopathies. Atorvastatin is a known cholesterol-lowering agent with many pleiotropic actions including antioxidant properties. However, the impact of atorvastatin on myocardial oxidative stress is not well known. The aim of this study was to evaluate the role of atorvastatin in improving diabetes-induced oxidative stress in the myocardium. Male Wistar rats weighing 20–25 g were randomly divided into four groups as normal, normal-treated, diabetes, and diabetes-treated. Induction of diabetes was performed by a single dose of streptozotocin (40 mg/kg, i.v.). Treated animals received atorvastatin for 8 weeks orally (40 mg/kg/day). After 8 weeks, animals were sacrificed and myocardial tissues were removed. Then, nitrate, glutathione (GSH), and malondialdehyde (MDA) contents as well as enzymatic activities of catalase (CAT) and superoxide dismutase (SOD) in the myocardial tissues were determined. Diabetes-induced oxidative stress by increasing nitrous free radicals (nitrate) (
p
≤ 0.001) and MDA content (
p
≤ 0.001), but had no significant effects on SOD, CAT, and GSH activities. Atorvastatin treatment in diabetic animals decreased free radical-induced damages by decreasing nitrate and MDA content and increasing GSH and SOD activities compared to control non-diabetic animals. Uncontrolled hyperglycemia induces oxidative burden in myocardium. Treatment by atorvastatin decreases oxidative and nitrosative stress in the myocardium of diabetic animals.</abstract><cop>London</cop><pub>Springer London</pub><doi>10.1007/s00580-018-2652-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid></addata></record> |
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| subjects | Antioxidants Atorvastatin Catalase Cholesterol Diabetes Diabetes mellitus Free radicals Glutathione Hematology Hyperglycemia Malondialdehyde Medicine Medicine & Public Health Myocardium Nitrates Oncology Original Article Oxidative stress Pathology Rodents Streptozocin Superoxide dismutase |
| title | Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats |
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