Yeast-based genotoxicity tests for assessing DNA alterations and DNA stress responses: a 40-year overview

By damaging DNA molecules, genotoxicants cause genetic mutations and also increase human susceptibility to cancers and genetic diseases. Over the past four decades, several assays have been developed in the budding yeast Saccharomyces cerevisiae to screen potential genotoxic substances and provide a...

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Veröffentlicht in:	Applied microbiology and biotechnology 2018-03, Vol.102 (6), p.2493-2507
1. Verfasser:	Eki, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Assaying Baking yeast Biomedical and Life Sciences Biotechnology Carcinogenicity Carcinogens Cell walls Cytochrome P450 Damage assessment Deoxyribonucleic acid DNA DNA damage DNA repair Drug development Ectopic expression Environmental testing Gene expression Genotoxicity Kinases Life Sciences Mammals Microbial Genetics and Genomics Microbiology Microfluidics Mini-Review Mutation Permeability Repair Saccharomyces cerevisiae Transcription activation Yeast Yeasts
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