Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour
To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated...
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| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2018-03, Vol.46 (2), p.255-262 |
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| container_title | Artificial cells, nanomedicine, and biotechnology |
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| creator | Guo, Dawei Dou, Dandan Li, Xinyu Zhang, Qian Bhutto, Zohaib Ahmed Wang, Liping |
| description | To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). The cumulative permeation of IVM across excised rat skin from SLNs was significantly increased compared to the ivermection suspension. These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies. |
| doi_str_mv | 10.1080/21691401.2017.1307207 |
| format | Article |
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These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies.</description><subject>Drug delivery</subject><subject>Encapsulation</subject><subject>Ivermectin</subject><subject>Nanoparticles</subject><subject>Scabies</subject><subject>Skin</subject><subject>Solid lipid nanoparticles</subject><subject>Stability</subject><subject>Toxicity</subject><subject>transdermal drug delivery</subject><subject>Transdermal medication</subject><subject>ultrasonic technique</subject><subject>Ultrasonic testing</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMoKupPUAbcOjV3MpOHK6X4KAhuXLgLaZLBSDoZk7TSf29KW5cGkntzOfcc-BC6BDwBzPFtA1RAi2HSYGATIJg1mB2g0828hhY-Dv96DCfoIqUvXA4Hyrr2GJ00nFBOO3aKxtnKxoXV2YWh9kEZa6oUvDOVd2N5BzWEUcXstLfprhqjLT-1Ud9U-rO0Otvo0m6Sspo77_K6UoOpclRDMsVe-WpuP9XKhWU8R0e98sle7OoZen96fJ--1K9vz7Ppw2ut2xZyramgrVIKG1EuEQxYh21LO20s6y0HIJ3tRUesIJwLQ2kHhhFN5qIxHMgZut7ajjF8L23K8quEDyVRghACGAcsiqrbqnQMKUXbyzG6hYprCVhuSMs9abkhLXeky97Vzn05X1jzt7XnWgT3W4Eb-lAA_ITojcxq7UPsCxbtkiT_Z_wCWv-Okg</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Guo, Dawei</creator><creator>Dou, Dandan</creator><creator>Li, Xinyu</creator><creator>Zhang, Qian</creator><creator>Bhutto, Zohaib Ahmed</creator><creator>Wang, Liping</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201803</creationdate><title>Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour</title><author>Guo, Dawei ; Dou, Dandan ; Li, Xinyu ; Zhang, Qian ; Bhutto, Zohaib Ahmed ; Wang, Liping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-c6964aaa0d9a0d3971750e465cde7fe81135ef953e93889d6651d73c3b92d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Drug delivery</topic><topic>Encapsulation</topic><topic>Ivermectin</topic><topic>Nanoparticles</topic><topic>Scabies</topic><topic>Skin</topic><topic>Solid lipid nanoparticles</topic><topic>Stability</topic><topic>Toxicity</topic><topic>transdermal drug delivery</topic><topic>Transdermal medication</topic><topic>ultrasonic technique</topic><topic>Ultrasonic testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Dawei</creatorcontrib><creatorcontrib>Dou, Dandan</creatorcontrib><creatorcontrib>Li, Xinyu</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Bhutto, Zohaib Ahmed</creatorcontrib><creatorcontrib>Wang, Liping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Dawei</au><au>Dou, Dandan</au><au>Li, Xinyu</au><au>Zhang, Qian</au><au>Bhutto, Zohaib Ahmed</au><au>Wang, Liping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>46</volume><issue>2</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. 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| identifier | ISSN: 2169-1401 |
| ispartof | Artificial cells, nanomedicine, and biotechnology, 2018-03, Vol.46 (2), p.255-262 |
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| source | Alma/SFX Local Collection |
| subjects | Drug delivery Encapsulation Ivermectin Nanoparticles Scabies Skin Solid lipid nanoparticles Stability Toxicity transdermal drug delivery Transdermal medication ultrasonic technique Ultrasonic testing |
| title | Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour |
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