Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P

Children raised with extended exposure to environmental tobacco smoke (ETS) experience increased cough and wheeze. This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mec...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2004-02, Vol.169 (4), p.499-504
Hauptverfasser:	Joad, Jesse P, Munch, Paul A, Bric, John M, Evans, Samuel J, Pinkerton, Kent E, Chen, Chao-Yin, Bonham, Ann C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aerosols Age Age Factors Airway management Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Brain Stem - metabolism Bronchoconstriction - physiology Citric Acid Cough - chemically induced Cough - etiology Cough - physiopathology Guinea Pigs Homocysteine - analogs & derivatives Homocysteine - pharmacology Injections Intensive care medicine Lung - innervation Male Medical sciences Neurokinin-1 Receptor Antagonists Neurons, Afferent - metabolism Piperidines - pharmacology Quinuclidines - pharmacology Receptors, Neurokinin-1 - physiology Respiration - drug effects Solitary Nucleus - physiology Substance P - metabolism Substance P - pharmacology Substance P - physiology Tobacco smoke Tobacco Smoke Pollution - adverse effects
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