Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P
Children raised with extended exposure to environmental tobacco smoke (ETS) experience increased cough and wheeze. This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mec...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-02, Vol.169 (4), p.499-504 |
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| creator | Joad, Jesse P Munch, Paul A Bric, John M Evans, Samuel J Pinkerton, Kent E Chen, Chao-Yin Bonham, Ann C |
| description | Children raised with extended exposure to environmental tobacco smoke (ETS) experience increased cough and wheeze. This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mechanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius. Guinea pigs were exposed to ETS from 1 to 6 weeks of age. At 5 weeks of age, guide cannulae were implanted bilaterally in the medial nucleus tractus solitarius at a site that produced apnea in response to the glutamate agonist D,L-homocysteic acid. At 6 weeks of age, either vehicle or a NK-1 receptor antagonist, SR 140333, was injected into the nucleus tractus solitarius of the conscious guinea pigs who were then exposed to citric acid aerosol. ETS exposure significantly enhanced citric acid-induced cough by 56% and maximal Penh (a measure of airway obstruction) by 43%, effects that were attenuated by the NK-1 receptor antagonist in the nucleus tractus solitarius. We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and bronchoconstriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius. |
| doi_str_mv | 10.1164/rccm.200308-1139OC |
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This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mechanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius. Guinea pigs were exposed to ETS from 1 to 6 weeks of age. At 5 weeks of age, guide cannulae were implanted bilaterally in the medial nucleus tractus solitarius at a site that produced apnea in response to the glutamate agonist D,L-homocysteic acid. At 6 weeks of age, either vehicle or a NK-1 receptor antagonist, SR 140333, was injected into the nucleus tractus solitarius of the conscious guinea pigs who were then exposed to citric acid aerosol. ETS exposure significantly enhanced citric acid-induced cough by 56% and maximal Penh (a measure of airway obstruction) by 43%, effects that were attenuated by the NK-1 receptor antagonist in the nucleus tractus solitarius. We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and bronchoconstriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200308-1139OC</identifier><identifier>PMID: 14644932</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Acids ; Aerosols ; Age ; Age Factors ; Airway management ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Brain Stem - metabolism ; Bronchoconstriction - physiology ; Citric Acid ; Cough - chemically induced ; Cough - etiology ; Cough - physiopathology ; Guinea Pigs ; Homocysteine - analogs & derivatives ; Homocysteine - pharmacology ; Injections ; Intensive care medicine ; Lung - innervation ; Male ; Medical sciences ; Neurokinin-1 Receptor Antagonists ; Neurons, Afferent - metabolism ; Piperidines - pharmacology ; Quinuclidines - pharmacology ; Receptors, Neurokinin-1 - physiology ; Respiration - drug effects ; Solitary Nucleus - physiology ; Substance P - metabolism ; Substance P - pharmacology ; Substance P - physiology ; Tobacco smoke ; Tobacco Smoke Pollution - adverse effects</subject><ispartof>American journal of respiratory and critical care medicine, 2004-02, Vol.169 (4), p.499-504</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Feb 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-fc92bd88cf1146c4bf6fd69544e12a18d72851b4cccfd288301dd8c43d599b013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4025,4026,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15514757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14644932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joad, Jesse P</creatorcontrib><creatorcontrib>Munch, Paul A</creatorcontrib><creatorcontrib>Bric, John M</creatorcontrib><creatorcontrib>Evans, Samuel J</creatorcontrib><creatorcontrib>Pinkerton, Kent E</creatorcontrib><creatorcontrib>Chen, Chao-Yin</creatorcontrib><creatorcontrib>Bonham, Ann C</creatorcontrib><title>Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Children raised with extended exposure to environmental tobacco smoke (ETS) experience increased cough and wheeze. This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mechanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius. Guinea pigs were exposed to ETS from 1 to 6 weeks of age. At 5 weeks of age, guide cannulae were implanted bilaterally in the medial nucleus tractus solitarius at a site that produced apnea in response to the glutamate agonist D,L-homocysteic acid. At 6 weeks of age, either vehicle or a NK-1 receptor antagonist, SR 140333, was injected into the nucleus tractus solitarius of the conscious guinea pigs who were then exposed to citric acid aerosol. ETS exposure significantly enhanced citric acid-induced cough by 56% and maximal Penh (a measure of airway obstruction) by 43%, effects that were attenuated by the NK-1 receptor antagonist in the nucleus tractus solitarius. We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and bronchoconstriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius.</description><subject>Acids</subject><subject>Aerosols</subject><subject>Age</subject><subject>Age Factors</subject><subject>Airway management</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - metabolism</subject><subject>Bronchoconstriction - physiology</subject><subject>Citric Acid</subject><subject>Cough - chemically induced</subject><subject>Cough - etiology</subject><subject>Cough - physiopathology</subject><subject>Guinea Pigs</subject><subject>Homocysteine - analogs & derivatives</subject><subject>Homocysteine - pharmacology</subject><subject>Injections</subject><subject>Intensive care medicine</subject><subject>Lung - innervation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurokinin-1 Receptor Antagonists</subject><subject>Neurons, Afferent - metabolism</subject><subject>Piperidines - pharmacology</subject><subject>Quinuclidines - pharmacology</subject><subject>Receptors, Neurokinin-1 - physiology</subject><subject>Respiration - drug effects</subject><subject>Solitary Nucleus - physiology</subject><subject>Substance P - metabolism</subject><subject>Substance P - pharmacology</subject><subject>Substance P - physiology</subject><subject>Tobacco smoke</subject><subject>Tobacco Smoke Pollution - adverse effects</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkE1v1DAQhi1ERUvLH-CALCQOHFI8tpPY3MqqlEqVumpBgguW449dL0lc7ISq_x6vslJPY42eeWf8IPQWyDlAwz8lY4ZzSggjogJg8nb1Ap1AzeqKy5a8LG_Ssopz-fMYvc55RwhQAeQVOgbelDajJ-j3Wucc_jl8P8Q_Dl9678yUcRzxKs6bLdajxRchPeqnjMOIf8V53OCrOYxO43XY5M_4LvYOR4-_JB3GPLkB389dnvRoHF6foSOv--zeHOop-vH18vvqW3Vze3W9uripDG3ZVHkjaWeFMB7KaYZ3vvG2kTXnDqgGYVsqaui4McZbKgQjYK0wnNlayo4AO0Xvl9yHFP_OLk9qF-c0lpUKpGwIlQ0tEF0gk2LOyXn1kMKg05MCovZG1d6oWoyqxWgZendInrvB2eeRg8ICfDgAOhvd-1R-HvIzV9fA27ot3MeF24bN9jEkp_Kg-77EgtK7_WZopOKKS8n-A-s3jKA</recordid><startdate>20040215</startdate><enddate>20040215</enddate><creator>Joad, Jesse P</creator><creator>Munch, Paul A</creator><creator>Bric, John M</creator><creator>Evans, Samuel J</creator><creator>Pinkerton, Kent E</creator><creator>Chen, Chao-Yin</creator><creator>Bonham, Ann C</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20040215</creationdate><title>Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P</title><author>Joad, Jesse P ; Munch, Paul A ; Bric, John M ; Evans, Samuel J ; Pinkerton, Kent E ; Chen, Chao-Yin ; Bonham, Ann C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-fc92bd88cf1146c4bf6fd69544e12a18d72851b4cccfd288301dd8c43d599b013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acids</topic><topic>Aerosols</topic><topic>Age</topic><topic>Age Factors</topic><topic>Airway management</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - metabolism</topic><topic>Bronchoconstriction - physiology</topic><topic>Citric Acid</topic><topic>Cough - chemically induced</topic><topic>Cough - etiology</topic><topic>Cough - physiopathology</topic><topic>Guinea Pigs</topic><topic>Homocysteine - analogs & derivatives</topic><topic>Homocysteine - pharmacology</topic><topic>Injections</topic><topic>Intensive care medicine</topic><topic>Lung - innervation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurokinin-1 Receptor Antagonists</topic><topic>Neurons, Afferent - metabolism</topic><topic>Piperidines - pharmacology</topic><topic>Quinuclidines - pharmacology</topic><topic>Receptors, Neurokinin-1 - physiology</topic><topic>Respiration - drug effects</topic><topic>Solitary Nucleus - physiology</topic><topic>Substance P - metabolism</topic><topic>Substance P - pharmacology</topic><topic>Substance P - physiology</topic><topic>Tobacco smoke</topic><topic>Tobacco Smoke Pollution - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joad, Jesse P</creatorcontrib><creatorcontrib>Munch, Paul A</creatorcontrib><creatorcontrib>Bric, John M</creatorcontrib><creatorcontrib>Evans, Samuel J</creatorcontrib><creatorcontrib>Pinkerton, Kent E</creatorcontrib><creatorcontrib>Chen, Chao-Yin</creatorcontrib><creatorcontrib>Bonham, Ann C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joad, Jesse P</au><au>Munch, Paul A</au><au>Bric, John M</au><au>Evans, Samuel J</au><au>Pinkerton, Kent E</au><au>Chen, Chao-Yin</au><au>Bonham, Ann C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2004-02-15</date><risdate>2004</risdate><volume>169</volume><issue>4</issue><spage>499</spage><epage>504</epage><pages>499-504</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Children raised with extended exposure to environmental tobacco smoke (ETS) experience increased cough and wheeze. This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mechanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius. Guinea pigs were exposed to ETS from 1 to 6 weeks of age. At 5 weeks of age, guide cannulae were implanted bilaterally in the medial nucleus tractus solitarius at a site that produced apnea in response to the glutamate agonist D,L-homocysteic acid. At 6 weeks of age, either vehicle or a NK-1 receptor antagonist, SR 140333, was injected into the nucleus tractus solitarius of the conscious guinea pigs who were then exposed to citric acid aerosol. ETS exposure significantly enhanced citric acid-induced cough by 56% and maximal Penh (a measure of airway obstruction) by 43%, effects that were attenuated by the NK-1 receptor antagonist in the nucleus tractus solitarius. We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and bronchoconstriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>14644932</pmid><doi>10.1164/rccm.200308-1139OC</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 2004-02, Vol.169 (4), p.499-504 |
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| source | MEDLINE; American Thoracic Society Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Acids Aerosols Age Age Factors Airway management Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Brain Stem - metabolism Bronchoconstriction - physiology Citric Acid Cough - chemically induced Cough - etiology Cough - physiopathology Guinea Pigs Homocysteine - analogs & derivatives Homocysteine - pharmacology Injections Intensive care medicine Lung - innervation Male Medical sciences Neurokinin-1 Receptor Antagonists Neurons, Afferent - metabolism Piperidines - pharmacology Quinuclidines - pharmacology Receptors, Neurokinin-1 - physiology Respiration - drug effects Solitary Nucleus - physiology Substance P - metabolism Substance P - pharmacology Substance P - physiology Tobacco smoke Tobacco Smoke Pollution - adverse effects |
| title | Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P |
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