A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors
Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-12, Vol.170 (12), p.1324-1330 |
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| creator | Newman, Lee S Rose, Cecile S Bresnitz, Eddy A Rossman, Milton D Barnard, Juliana Frederick, Margaret Terrin, Michael L Weinberger, Steven E Moller, David R McLennan, Geoffrey Hunninghake, Gary DePalo, Louis Baughman, Robert P Iannuzzi, Michael C Judson, Marc A Knatterud, Genell L Thompson, Bruce W Teirstein, Alvin S Yeager, Henry, Jr Johns, Carol J Rabin, David L Rybicki, Benjamin A Cherniack, Reuben ACCESS Research Group |
| description | Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols. |
| doi_str_mv | 10.1164/rccm.200402-249OC |
| format | Article |
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We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200402-249OC</identifier><identifier>PMID: 15347561</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens ; Beryllium ; Biological and medical sciences ; Biopsy ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Case-Control Studies ; Disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Employment ; Enrollments ; Environmental Exposure - adverse effects ; Female ; Granulomas ; Hematologic and hematopoietic diseases ; Humans ; Hypotheses ; Insecticides ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Occupational Exposure - adverse effects ; Occupations ; Patients ; Platelet diseases and coagulopathies ; Questionnaires ; Risk Factors ; Sarcoidosis ; Sarcoidosis - etiology</subject><ispartof>American journal of respiratory and critical care medicine, 2004-12, Vol.170 (12), p.1324-1330</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Thoracic Society Dec 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-7c576224f80b805c08ae2d1b6970e56b96e36495ae9213cbfba73a5f5a0dd1483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16361009$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15347561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newman, Lee S</creatorcontrib><creatorcontrib>Rose, Cecile S</creatorcontrib><creatorcontrib>Bresnitz, Eddy A</creatorcontrib><creatorcontrib>Rossman, Milton D</creatorcontrib><creatorcontrib>Barnard, Juliana</creatorcontrib><creatorcontrib>Frederick, Margaret</creatorcontrib><creatorcontrib>Terrin, Michael L</creatorcontrib><creatorcontrib>Weinberger, Steven E</creatorcontrib><creatorcontrib>Moller, David R</creatorcontrib><creatorcontrib>McLennan, Geoffrey</creatorcontrib><creatorcontrib>Hunninghake, Gary</creatorcontrib><creatorcontrib>DePalo, Louis</creatorcontrib><creatorcontrib>Baughman, Robert P</creatorcontrib><creatorcontrib>Iannuzzi, Michael C</creatorcontrib><creatorcontrib>Judson, Marc A</creatorcontrib><creatorcontrib>Knatterud, Genell L</creatorcontrib><creatorcontrib>Thompson, Bruce W</creatorcontrib><creatorcontrib>Teirstein, Alvin S</creatorcontrib><creatorcontrib>Yeager, Henry, Jr</creatorcontrib><creatorcontrib>Johns, Carol J</creatorcontrib><creatorcontrib>Rabin, David L</creatorcontrib><creatorcontrib>Rybicki, Benjamin A</creatorcontrib><creatorcontrib>Cherniack, Reuben</creatorcontrib><creatorcontrib>ACCESS Research Group</creatorcontrib><creatorcontrib>ACCESS Research Group</creatorcontrib><title>A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antigens</subject><subject>Beryllium</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Disease</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Employment</subject><subject>Enrollments</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Granulomas</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Insecticides</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupations</subject><subject>Patients</subject><subject>Platelet diseases and coagulopathies</subject><subject>Questionnaires</subject><subject>Risk Factors</subject><subject>Sarcoidosis</subject><subject>Sarcoidosis - etiology</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpFkF1rFDEUhoMotlZ_gDcSBK9kak6-ZuJdGbYqFBasgngTzmQybdaZyZrMKP33Zt2FXiWE531zzkPIa2CXAFp-SM5Nl5wxyXjFpdm2T8g5KKEqaWr2tNxZLSopzY8z8iLnHWPAG2DPyVmBZK00nJOfV7TF7Gkb5yXFkW6WEMd4Fxy9Xdb-gcaB3mJyMfQxh_yRbuY_IcV58vOCI8W5p1vn1j2W2Fwevob8i16jW2LKL8mzAcfsX53OC_L9evOt_VzdbD99aa9uKiekXKraqVpzLoeGdQ1TjjXoeQ-dLjt4pTujvdDSKPSGg3Dd0GEtUA0KWd-DbMQFeXvs3af4e_V5sbu4pjJNtmCMMmXtAwRHyKWYc_KD3acwYXqwwOxBpj3ItEeZ9r_MknlzKl67yfePiZO9Arw7AZgdjkPC2YX8yGmhgTFTuPdH7j7c3f8Nyds84TiWWrC4O3wMdZmCWxBcin-PgovA</recordid><startdate>20041215</startdate><enddate>20041215</enddate><creator>Newman, Lee S</creator><creator>Rose, Cecile S</creator><creator>Bresnitz, Eddy A</creator><creator>Rossman, Milton D</creator><creator>Barnard, Juliana</creator><creator>Frederick, Margaret</creator><creator>Terrin, Michael L</creator><creator>Weinberger, Steven E</creator><creator>Moller, David R</creator><creator>McLennan, Geoffrey</creator><creator>Hunninghake, Gary</creator><creator>DePalo, Louis</creator><creator>Baughman, Robert P</creator><creator>Iannuzzi, Michael C</creator><creator>Judson, Marc A</creator><creator>Knatterud, Genell L</creator><creator>Thompson, Bruce W</creator><creator>Teirstein, Alvin S</creator><creator>Yeager, Henry, Jr</creator><creator>Johns, Carol J</creator><creator>Rabin, David L</creator><creator>Rybicki, Benjamin A</creator><creator>Cherniack, Reuben</creator><creator>ACCESS Research Group</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20041215</creationdate><title>A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors</title><author>Newman, Lee S ; Rose, Cecile S ; Bresnitz, Eddy A ; Rossman, Milton D ; Barnard, Juliana ; Frederick, Margaret ; Terrin, Michael L ; Weinberger, Steven E ; Moller, David R ; McLennan, Geoffrey ; Hunninghake, Gary ; DePalo, Louis ; Baughman, Robert P ; Iannuzzi, Michael C ; Judson, Marc A ; Knatterud, Genell L ; Thompson, Bruce W ; Teirstein, Alvin S ; Yeager, Henry, Jr ; Johns, Carol J ; Rabin, David L ; Rybicki, Benjamin A ; Cherniack, Reuben ; ACCESS Research Group</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-7c576224f80b805c08ae2d1b6970e56b96e36495ae9213cbfba73a5f5a0dd1483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. 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Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2004-12-15</date><risdate>2004</risdate><volume>170</volume><issue>12</issue><spage>1324</spage><epage>1330</epage><pages>1324-1330</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>15347561</pmid><doi>10.1164/rccm.200402-249OC</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1073-449X |
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| issn | 1073-449X 1535-4970 |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens Beryllium Biological and medical sciences Biopsy Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Employment Enrollments Environmental Exposure - adverse effects Female Granulomas Hematologic and hematopoietic diseases Humans Hypotheses Insecticides Intensive care medicine Male Medical sciences Middle Aged Multivariate Analysis Occupational Exposure - adverse effects Occupations Patients Platelet diseases and coagulopathies Questionnaires Risk Factors Sarcoidosis Sarcoidosis - etiology |
| title | A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors |
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