Sitaxsentan Therapy for Pulmonary Arterial Hypertension

Sitaxsentan may benefit patients with pulmonary arterial hypertension by blocking the vasoconstrictor effects of endothelin-A while maintaining the vasodilator/clearance functions of endothelin-B receptors. Patients with pulmonary arterial hypertension that was idiopathic, related to connective tiss...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2004-02, Vol.169 (4), p.441-447
Hauptverfasser:	Barst, Robyn J, Langleben, David, Frost, Adaani, Horn, Evelyn M, Oudiz, Ronald, Shapiro, Shelley, McLaughlin, Vallerie, Hill, Nicholas, Tapson, Victor F, Robbins, Ivan M, Zwicke, Diane, Duncan, Benjamin, Dixon, Richard A. F, Frumkin, Lyn R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anaerobic Threshold Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Double-Blind Method Endothelin Receptor Antagonists Exercise Test Exercise Tolerance Female Hemodynamics Humans Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - physiopathology Intensive care medicine Isoxazoles - adverse effects Isoxazoles - therapeutic use Male Medical sciences Middle Aged Oxygen Consumption Thiophenes - adverse effects Thiophenes - therapeutic use
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