Desipramine induces apoptosis in hepatocellular carcinoma cells

Antitumor effects of antidepressants have been reported in many cancer cell lines. However, anti-proliferative effects of desipramine, a tricyclic antidepressant, in hepatocellular carcinoma are currently unknown. In this study, we examined the effects of desipramine in human hepatoma Hep3B cells. T...

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Veröffentlicht in:	Oncology reports 2017-08, Vol.38 (2), p.1029-1034
Hauptverfasser:	Yang, Dong Kwon, Kim, Shang-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressants Antidepressive Agents, Tricyclic - pharmacology Apoptosis Apoptosis - drug effects Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation - drug effects Cellular signal transduction Chemotherapy Cytotoxicity Desipramine Desipramine - pharmacology Development and progression Drug therapy Health aspects Hep3B cells Hepatocellular carcinoma Humans Life sciences Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Membrane Potential, Mitochondrial - drug effects Mitochondria Mitogen-Activated Protein Kinases - metabolism Patient outcomes Reactive oxygen species Reactive Oxygen Species - metabolism Tumor Cells, Cultured
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