Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions
In this paper, we present the results obtained during the investigation of thermal stability of antiparkinsonian drug Levodopa in oxidative atmosphere and under non-isothermal conditions. As investigational tools, thermoanalytical methods were used along with ATR-FTIR spectroscopy and later complete...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2018-02, Vol.131 (2), p.1881-1888 |
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| container_title | Journal of thermal analysis and calorimetry |
| container_volume | 131 |
| creator | Ledeti, Adriana Olariu, Tudor Caunii, Angelica Vlase, Gabriela Circioban, Denisa Baul, Bianca Ledeti, Ionut Vlase, Titus Murariu, Marius |
| description | In this paper, we present the results obtained during the investigation of thermal stability of antiparkinsonian drug Levodopa in oxidative atmosphere and under non-isothermal conditions. As investigational tools, thermoanalytical methods were used along with ATR-FTIR spectroscopy and later completed with kinetic study for the main degradative process that occurs in the 260–330 °C temperature range, at four heating rates. Four kinetic methods were used as follows: ASTM E698 which leads to an activation energy of 209.72 kJ mol
−1
, while isoconversional methods suggested the values 177.6 ± 13.1 kJ mol
−1
(Friedman) and 188.8 ± 4.5 kJ mol
−1
(Kissinger–Akahira–Sunose), with a clear indication of multistep degradation. The last method used was NPK, which revealed that the degradation occurs in three steps, with different physical and chemical contributions with mean activation energy equal to 191.3 ± 9.5 kJ mol
−1
. |
| doi_str_mv | 10.1007/s10973-017-6671-z |
| format | Article |
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−1
, while isoconversional methods suggested the values 177.6 ± 13.1 kJ mol
−1
(Friedman) and 188.8 ± 4.5 kJ mol
−1
(Kissinger–Akahira–Sunose), with a clear indication of multistep degradation. The last method used was NPK, which revealed that the degradation occurs in three steps, with different physical and chemical contributions with mean activation energy equal to 191.3 ± 9.5 kJ mol
−1
.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>DOI: 10.1007/s10973-017-6671-z</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Activation energy ; Analysis ; Analytical Chemistry ; Chemistry ; Chemistry and Materials Science ; Degradation ; Fourier transforms ; Inorganic Chemistry ; Kinetics ; L-dopa ; Measurement Science and Instrumentation ; Physical Chemistry ; Polymer Sciences ; Stability analysis ; Temperature ; Thermal stability</subject><ispartof>Journal of thermal analysis and calorimetry, 2018-02, Vol.131 (2), p.1881-1888</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2017</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-ffdd0652fc28098277bd21c610f5e48f6ef5f57cb9f8fb3bc86d7f5a820382b13</citedby><cites>FETCH-LOGICAL-c454t-ffdd0652fc28098277bd21c610f5e48f6ef5f57cb9f8fb3bc86d7f5a820382b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-017-6671-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-017-6671-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Ledeti, Adriana</creatorcontrib><creatorcontrib>Olariu, Tudor</creatorcontrib><creatorcontrib>Caunii, Angelica</creatorcontrib><creatorcontrib>Vlase, Gabriela</creatorcontrib><creatorcontrib>Circioban, Denisa</creatorcontrib><creatorcontrib>Baul, Bianca</creatorcontrib><creatorcontrib>Ledeti, Ionut</creatorcontrib><creatorcontrib>Vlase, Titus</creatorcontrib><creatorcontrib>Murariu, Marius</creatorcontrib><title>Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>In this paper, we present the results obtained during the investigation of thermal stability of antiparkinsonian drug Levodopa in oxidative atmosphere and under non-isothermal conditions. As investigational tools, thermoanalytical methods were used along with ATR-FTIR spectroscopy and later completed with kinetic study for the main degradative process that occurs in the 260–330 °C temperature range, at four heating rates. Four kinetic methods were used as follows: ASTM E698 which leads to an activation energy of 209.72 kJ mol
−1
, while isoconversional methods suggested the values 177.6 ± 13.1 kJ mol
−1
(Friedman) and 188.8 ± 4.5 kJ mol
−1
(Kissinger–Akahira–Sunose), with a clear indication of multistep degradation. The last method used was NPK, which revealed that the degradation occurs in three steps, with different physical and chemical contributions with mean activation energy equal to 191.3 ± 9.5 kJ mol
−1
.</description><subject>Activation energy</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Degradation</subject><subject>Fourier transforms</subject><subject>Inorganic Chemistry</subject><subject>Kinetics</subject><subject>L-dopa</subject><subject>Measurement Science and Instrumentation</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Stability analysis</subject><subject>Temperature</subject><subject>Thermal stability</subject><issn>1388-6150</issn><issn>1588-2926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU1rGzEQhpeSQpO0P6C3hZ56WGekXWmlozFpGjAEkvYstPpwlawlV5JD7F9fmU1JDAk6aBDPM2LmraqvCGYIoL9ICHjfNoD6htIeNfsP1SkijDWYY3pS6rbUFBH4VJ2ldA8AnAM6rfTloxy3Mrvg62Dr_MfEtRzrlOXgRpd3tfS6fnDeZKcOgDarKPXE2xDr0TwGHTaydr72wTcuhf89VPDaHcD0ufpo5ZjMl-f7vPr94_LX4mezvLm6XsyXjepIlxtrtQZKsFWYAWe47weNkaIILDEds9RYYkmvBm6ZHdpBMap7SyTD0DI8oPa8-jb13cTwd2tSFvdhG335UiDOu7ICBvBCreRohPM25CjV2iUl5gTTjrdloYWavUGVo83aldGMdeX9SPh-JBQmm6e8ktuUxPXd7TGLJlbFkFI0VmyiW8u4EwjEIU8x5SlKnuKQp9gXB09OKqxfmfhquHelf95Ios0</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Ledeti, Adriana</creator><creator>Olariu, Tudor</creator><creator>Caunii, Angelica</creator><creator>Vlase, Gabriela</creator><creator>Circioban, Denisa</creator><creator>Baul, Bianca</creator><creator>Ledeti, Ionut</creator><creator>Vlase, Titus</creator><creator>Murariu, Marius</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20180201</creationdate><title>Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions</title><author>Ledeti, Adriana ; Olariu, Tudor ; Caunii, Angelica ; Vlase, Gabriela ; Circioban, Denisa ; Baul, Bianca ; Ledeti, Ionut ; Vlase, Titus ; Murariu, Marius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-ffdd0652fc28098277bd21c610f5e48f6ef5f57cb9f8fb3bc86d7f5a820382b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation energy</topic><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Degradation</topic><topic>Fourier transforms</topic><topic>Inorganic Chemistry</topic><topic>Kinetics</topic><topic>L-dopa</topic><topic>Measurement Science and Instrumentation</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Stability analysis</topic><topic>Temperature</topic><topic>Thermal stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ledeti, Adriana</creatorcontrib><creatorcontrib>Olariu, Tudor</creatorcontrib><creatorcontrib>Caunii, Angelica</creatorcontrib><creatorcontrib>Vlase, Gabriela</creatorcontrib><creatorcontrib>Circioban, Denisa</creatorcontrib><creatorcontrib>Baul, Bianca</creatorcontrib><creatorcontrib>Ledeti, Ionut</creatorcontrib><creatorcontrib>Vlase, Titus</creatorcontrib><creatorcontrib>Murariu, Marius</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ledeti, Adriana</au><au>Olariu, Tudor</au><au>Caunii, Angelica</au><au>Vlase, Gabriela</au><au>Circioban, Denisa</au><au>Baul, Bianca</au><au>Ledeti, Ionut</au><au>Vlase, Titus</au><au>Murariu, Marius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2018-02-01</date><risdate>2018</risdate><volume>131</volume><issue>2</issue><spage>1881</spage><epage>1888</epage><pages>1881-1888</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><abstract>In this paper, we present the results obtained during the investigation of thermal stability of antiparkinsonian drug Levodopa in oxidative atmosphere and under non-isothermal conditions. As investigational tools, thermoanalytical methods were used along with ATR-FTIR spectroscopy and later completed with kinetic study for the main degradative process that occurs in the 260–330 °C temperature range, at four heating rates. Four kinetic methods were used as follows: ASTM E698 which leads to an activation energy of 209.72 kJ mol
−1
, while isoconversional methods suggested the values 177.6 ± 13.1 kJ mol
−1
(Friedman) and 188.8 ± 4.5 kJ mol
−1
(Kissinger–Akahira–Sunose), with a clear indication of multistep degradation. The last method used was NPK, which revealed that the degradation occurs in three steps, with different physical and chemical contributions with mean activation energy equal to 191.3 ± 9.5 kJ mol
−1
.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10973-017-6671-z</doi><tpages>8</tpages></addata></record> |
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| source | SpringerNature Journals |
| subjects | Activation energy Analysis Analytical Chemistry Chemistry Chemistry and Materials Science Degradation Fourier transforms Inorganic Chemistry Kinetics L-dopa Measurement Science and Instrumentation Physical Chemistry Polymer Sciences Stability analysis Temperature Thermal stability |
| title | Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions |
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