Hepatocyte nuclear factor 4a regulates the expression of intestinal epithelial Na+/H+ exchanger isoform 3

Na+/H+ exchanger isoform 3 (NHE3) plays a key role in coupled electroneutral NaCl absorption in the mammalian intestine. Reduced NHE3 expression or function has been implicated in the pathogenesis of diarrhea associated with inflammatory bowel disease (IBD) or enteric infections. Our previous studie...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2018-01, Vol.314 (1), p.G14
Hauptverfasser:	Muthusamy, Saminathan, Jeong, Jong Jin, Cheng, Ming, Bonzo, Jessica A, Kumar, Anoop, Gonzalez, Frank J, Borthakur, Alip, Dudeja, Pradeep K, Saksena, Seema, Malakooti, Jaleh
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatin Diarrhea Epithelial cells Gene expression Gene regulation Genes Hepatology Hydrogen Immunoprecipitation Inflammatory bowel diseases Interferon Intestine Mutagenesis Na+/H+-exchanging ATPase Nhe3 gene NHE3 protein Pathogenesis siRNA Sodium chloride Sp1 protein Transcription factors Tumor necrosis factor-α γ-Interferon
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