Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma
miRNA-221 is one of the over 700 kinds of currently known microRNAs (miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quant...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2017-01, Vol.18 (2), p.209-214 |
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| creator | Chen, Fan Li, Xin-Feng Fu, Dong-Sheng Huang, Jian-Guo Yang, Shun-E |
| description | miRNA-221 is one of the over 700 kinds of currently known microRNAs (miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para-carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients. miRNA-221 expression was significantly higher in HCC tissues than in adjacent tissues (P < 0.001). We analyzed the relationship between miRNA-221 expression level and clinicopathological characteristics of HCC patients. Our results suggested that miRNA-221 expression level was closely related to tumor stage (P = 0.012), number of tumor nodes (P = 0.018), and microvascular invasion (P = 0.010) in HCC patients. The results of survival analysis suggested that HCC patients with up-regulated miRNA-221 expression had a shorter survival time. The high miRNA-221 expression indicates the poor prognosis of HCC patients; thus, miRNA-221 can be regarded an important molecular marker for HCC prognosis. |
| doi_str_mv | 10.3233/CBM-161671 |
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Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para-carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients. miRNA-221 expression was significantly higher in HCC tissues than in adjacent tissues (P < 0.001). We analyzed the relationship between miRNA-221 expression level and clinicopathological characteristics of HCC patients. Our results suggested that miRNA-221 expression level was closely related to tumor stage (P = 0.012), number of tumor nodes (P = 0.018), and microvascular invasion (P = 0.010) in HCC patients. The results of survival analysis suggested that HCC patients with up-regulated miRNA-221 expression had a shorter survival time. The high miRNA-221 expression indicates the poor prognosis of HCC patients; thus, miRNA-221 can be regarded an important molecular marker for HCC prognosis.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-161671</identifier><identifier>PMID: 27983537</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Arsenic ; Biomarkers ; Biomarkers, Tumor - genetics ; Carcinogens ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Hepatocellular carcinoma ; Humans ; Kaplan-Meier Estimate ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Male ; Medical prognosis ; MicroRNAs - genetics ; Microvasculature ; Middle Aged ; miRNA ; Patients ; Polymerase chain reaction ; Prognosis ; Real-Time Polymerase Chain Reaction - methods ; Survival ; Survival analysis ; Tissues ; Tumors</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2017-01, Vol.18 (2), p.209-214</ispartof><rights>IOS Press and the authors. All rights reserved</rights><rights>Copyright IOS Press BV 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-60275ead6b135f6ab14539cb21b51c1bf53df98ecda43f23d3655b94bb6b68ca3</citedby><cites>FETCH-LOGICAL-c454t-60275ead6b135f6ab14539cb21b51c1bf53df98ecda43f23d3655b94bb6b68ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.3233/CBM-161671$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.3233/CBM-161671$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.3233/CBM-161671?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27983537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Fan</creatorcontrib><creatorcontrib>Li, Xin-Feng</creatorcontrib><creatorcontrib>Fu, Dong-Sheng</creatorcontrib><creatorcontrib>Huang, Jian-Guo</creatorcontrib><creatorcontrib>Yang, Shun-E</creatorcontrib><title>Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma</title><title>Cancer biomarkers : section A of Disease markers</title><addtitle>Cancer Biomark</addtitle><description>miRNA-221 is one of the over 700 kinds of currently known microRNAs (miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para-carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients. miRNA-221 expression was significantly higher in HCC tissues than in adjacent tissues (P < 0.001). We analyzed the relationship between miRNA-221 expression level and clinicopathological characteristics of HCC patients. Our results suggested that miRNA-221 expression level was closely related to tumor stage (P = 0.012), number of tumor nodes (P = 0.018), and microvascular invasion (P = 0.010) in HCC patients. The results of survival analysis suggested that HCC patients with up-regulated miRNA-221 expression had a shorter survival time. The high miRNA-221 expression indicates the poor prognosis of HCC patients; thus, miRNA-221 can be regarded an important molecular marker for HCC prognosis.</description><subject>Adult</subject><subject>Arsenic</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinogens</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>MicroRNAs - genetics</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction - methods</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Tissues</subject><subject>Tumors</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkF1LwzAUhoMobk5v_AES8EIQqk3SJM3lLH7BVBC9E0qSJjOza2bSCv57I5sieHXOxcP7nvMAcIjyM4IJOa8u7jLEEONoC4xRyWlWUoG30055keWIkhHYi3GR5wVBWOyCEeaiJJTwMXipWtc5LVu48r3pepc2b-HSPd5PM4wRlBFK2PkPk4jg552PvdNQOb-U4c0EaH2Ar2Yle69N2w6tDFDLoF2XgH2wY2UbzcFmTsDz1eVTdZPNHq5vq-ks0wUt-ozlmFMjG6YQoZZJhQpKhFYYKYo0UpaSxorS6EYWxGLSEEapEoVSTLFSSzIBx-vcdOH7YGJfL_wQulRZIyGI4DmnPFGna0oHH2Mwtl4Fl774rFFef4usk8h6LTLBR5vIQS1N84v-mEvAyRqIcm7-9P2P-gJfYXmU</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Chen, Fan</creator><creator>Li, Xin-Feng</creator><creator>Fu, Dong-Sheng</creator><creator>Huang, Jian-Guo</creator><creator>Yang, Shun-E</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20170101</creationdate><title>Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma</title><author>Chen, Fan ; Li, Xin-Feng ; Fu, Dong-Sheng ; Huang, Jian-Guo ; Yang, Shun-E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-60275ead6b135f6ab14539cb21b51c1bf53df98ecda43f23d3655b94bb6b68ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Arsenic</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinogens</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>MicroRNAs - genetics</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction - methods</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Tissues</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Fan</creatorcontrib><creatorcontrib>Li, Xin-Feng</creatorcontrib><creatorcontrib>Fu, Dong-Sheng</creatorcontrib><creatorcontrib>Huang, Jian-Guo</creatorcontrib><creatorcontrib>Yang, Shun-E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chen, Fan</au><au>Li, Xin-Feng</au><au>Fu, Dong-Sheng</au><au>Huang, Jian-Guo</au><au>Yang, Shun-E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>18</volume><issue>2</issue><spage>209</spage><epage>214</epage><pages>209-214</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>miRNA-221 is one of the over 700 kinds of currently known microRNAs (miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para-carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients. miRNA-221 expression was significantly higher in HCC tissues than in adjacent tissues (P < 0.001). We analyzed the relationship between miRNA-221 expression level and clinicopathological characteristics of HCC patients. Our results suggested that miRNA-221 expression level was closely related to tumor stage (P = 0.012), number of tumor nodes (P = 0.018), and microvascular invasion (P = 0.010) in HCC patients. The results of survival analysis suggested that HCC patients with up-regulated miRNA-221 expression had a shorter survival time. The high miRNA-221 expression indicates the poor prognosis of HCC patients; thus, miRNA-221 can be regarded an important molecular marker for HCC prognosis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>27983537</pmid><doi>10.3233/CBM-161671</doi><tpages>6</tpages></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Arsenic Biomarkers Biomarkers, Tumor - genetics Carcinogens Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Disease-Free Survival Female Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Humans Kaplan-Meier Estimate Liver cancer Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Male Medical prognosis MicroRNAs - genetics Microvasculature Middle Aged miRNA Patients Polymerase chain reaction Prognosis Real-Time Polymerase Chain Reaction - methods Survival Survival analysis Tissues Tumors |
| title | Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma |
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