A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver
A novel herbal beverage (HB) was formulated from blends of Moringa oleifera , Dennettia tripetala , and Citrus sinensis and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orall...
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| Veröffentlicht in: | Comparative clinical pathology 2018-05, Vol.27 (3), p.699-704 |
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| creator | Ebuehi, Osaretin A. T. Erukainure, Ochuko L. Adione, Rebecca Oyenihi, Ayodeji B. |
| description | A novel herbal beverage (HB) was formulated from blends of
Moringa oleifera
,
Dennettia tripetala
, and
Citrus sinensis
and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (
p
|
| doi_str_mv | 10.1007/s00580-018-2654-0 |
| format | Article |
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Moringa oleifera
,
Dennettia tripetala
, and
Citrus sinensis
and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (
p
< 0.05) reversed after treatment with HB. Treatment with HB led to significant (
p
< 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (
p
< 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.</description><identifier>ISSN: 1618-5641</identifier><identifier>EISSN: 1618-565X</identifier><identifier>DOI: 10.1007/s00580-018-2654-0</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Alanine transaminase ; Alkaline phosphatase ; Aspartate aminotransferase ; Bilirubin ; Brain injury ; Citrus sinensis ; Crude oil ; Dennettia tripetala ; Hematology ; Light effects ; Liver ; Malondialdehyde ; Medicine ; Medicine & Public Health ; Moringa oleifera ; Oncology ; Original Article ; Oxidation ; Pathology ; Quercetin ; Rodents ; Superoxide dismutase</subject><ispartof>Comparative clinical pathology, 2018-05, Vol.27 (3), p.699-704</ispartof><rights>Springer-Verlag London Ltd., part of Springer Nature 2018</rights><rights>Comparative Clinical Pathology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2310-437fdb2fd84ae9fdf897d8a3af1fe64d4aa9069a95e57be3d20d1d2ef3aff2cb3</citedby><cites>FETCH-LOGICAL-c2310-437fdb2fd84ae9fdf897d8a3af1fe64d4aa9069a95e57be3d20d1d2ef3aff2cb3</cites><orcidid>0000-0003-0489-338X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00580-018-2654-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00580-018-2654-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids></links><search><creatorcontrib>Ebuehi, Osaretin A. T.</creatorcontrib><creatorcontrib>Erukainure, Ochuko L.</creatorcontrib><creatorcontrib>Adione, Rebecca</creatorcontrib><creatorcontrib>Oyenihi, Ayodeji B.</creatorcontrib><title>A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver</title><title>Comparative clinical pathology</title><addtitle>Comp Clin Pathol</addtitle><description>A novel herbal beverage (HB) was formulated from blends of
Moringa oleifera
,
Dennettia tripetala
, and
Citrus sinensis
and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (
p
< 0.05) reversed after treatment with HB. Treatment with HB led to significant (
p
< 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (
p
< 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.</description><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Aspartate aminotransferase</subject><subject>Bilirubin</subject><subject>Brain injury</subject><subject>Citrus sinensis</subject><subject>Crude oil</subject><subject>Dennettia tripetala</subject><subject>Hematology</subject><subject>Light effects</subject><subject>Liver</subject><subject>Malondialdehyde</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Moringa oleifera</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Oxidation</subject><subject>Pathology</subject><subject>Quercetin</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><issn>1618-5641</issn><issn>1618-565X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UU1vFDEMHSEqUdr-AG6WuDIlmcznsV2gILXqBaTeIs_E2WY1TRYns-r-H34oWS2quPRk-_m9Z8mvKD5IcSmF6D5HIZpelEL2ZdU2dSneFKeyzVPTNg9vX_pavivex7gRQja9UqfFnyvwYUczPBKPOMNIO2JcE1gOT3AX2Pk1QpjJ2Yx_gi_kPaXkEBK7LSWcM4jewMolXiJE58lHFwFHTBThOni_h9mtHxNMvBiC4ObSebNMZCA8O4PJ7Qic3yy8zwUYE4yMuTvYznnJ58WJxTnSxb96Vvz69vXn6nt5e3_zY3V1W06VkqKsVWfNWFnT10iDNbYfOtOjQisttbWpEQfRDjg01HQjKVMJI01FNjNsNY3qrPh49N1y-L1QTHoTFvb5pJbDoNqmVbLLLHlkTRxiZLJ6y-4Jea-l0Icw9DEMncPQhzC0yJrqqInbw0eJ_3N-VfQXk8OQrw</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Ebuehi, Osaretin A. T.</creator><creator>Erukainure, Ochuko L.</creator><creator>Adione, Rebecca</creator><creator>Oyenihi, Ayodeji B.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-0489-338X</orcidid></search><sort><creationdate>20180501</creationdate><title>A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver</title><author>Ebuehi, Osaretin A. T. ; Erukainure, Ochuko L. ; Adione, Rebecca ; Oyenihi, Ayodeji B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2310-437fdb2fd84ae9fdf897d8a3af1fe64d4aa9069a95e57be3d20d1d2ef3aff2cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Aspartate aminotransferase</topic><topic>Bilirubin</topic><topic>Brain injury</topic><topic>Citrus sinensis</topic><topic>Crude oil</topic><topic>Dennettia tripetala</topic><topic>Hematology</topic><topic>Light effects</topic><topic>Liver</topic><topic>Malondialdehyde</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Moringa oleifera</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Oxidation</topic><topic>Pathology</topic><topic>Quercetin</topic><topic>Rodents</topic><topic>Superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebuehi, Osaretin A. T.</creatorcontrib><creatorcontrib>Erukainure, Ochuko L.</creatorcontrib><creatorcontrib>Adione, Rebecca</creatorcontrib><creatorcontrib>Oyenihi, Ayodeji B.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Comparative clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebuehi, Osaretin A. T.</au><au>Erukainure, Ochuko L.</au><au>Adione, Rebecca</au><au>Oyenihi, Ayodeji B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver</atitle><jtitle>Comparative clinical pathology</jtitle><stitle>Comp Clin Pathol</stitle><date>2018-05-01</date><risdate>2018</risdate><volume>27</volume><issue>3</issue><spage>699</spage><epage>704</epage><pages>699-704</pages><issn>1618-5641</issn><eissn>1618-565X</eissn><abstract>A novel herbal beverage (HB) was formulated from blends of
Moringa oleifera
,
Dennettia tripetala
, and
Citrus sinensis
and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (
p
< 0.05) reversed after treatment with HB. Treatment with HB led to significant (
p
< 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (
p
< 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.</abstract><cop>London</cop><pub>Springer London</pub><doi>10.1007/s00580-018-2654-0</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0489-338X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-5641 |
| ispartof | Comparative clinical pathology, 2018-05, Vol.27 (3), p.699-704 |
| issn | 1618-5641 1618-565X |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Alanine transaminase Alkaline phosphatase Aspartate aminotransferase Bilirubin Brain injury Citrus sinensis Crude oil Dennettia tripetala Hematology Light effects Liver Malondialdehyde Medicine Medicine & Public Health Moringa oleifera Oncology Original Article Oxidation Pathology Quercetin Rodents Superoxide dismutase |
| title | A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver |
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