Novel ^sup 18^F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of ^sup 18^F-LY2459989 in Nonhuman Primates

The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other central nervous system disorders and, thus, is an important target for drug development. We previously developed several 11C-labeled PET radiotracers for KOR imaging in humans. Here we report the synthesis and evalu...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2018-01, Vol.59 (1), p.140
Hauptverfasser:	Li, Songye, Cai, Zhengxin, Zheng, Ming-Qiang, Holden, Daniel, Naganawa, Mika, Lin, Shu-Fei, Ropchan, Jim, Labaree, David, Kapinos, Michael, Lara-Jaime, Teresa, Navarro, Antonio, Huang, Yiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonist drugs Brain Central nervous system Cerebellum Cortex (cingulate) Cortex (frontal) Drug development Evaluation Imaging Kinetics Mental depression Monkeys Narcotics Neuroimaging Opioid receptors Pharmacology Positron emission Positron emission tomography Primates Putamen Radiochemical analysis Selective binding Synthesis Temporal lobe Thalamus Tomography
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