Alterations in gene expression in vitamin D‐deficiency: Down‐regulation of liver Cyp7a1 and renal Oat3 in mice

The vitamin D‐deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D‐deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and liver cholesterol, and a reduction in cholester...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2018-02, Vol.39 (2), p.99-115
Hauptverfasser:	Quach, Holly P., Noh, Keumhan, Hoi, Stacie Y., Bruinsma, Adrie, Groothuis, Geny M.M., Li, Albert P., Chow, Edwin C.Y., Pang, K. Sandy
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcitriol Calcium Calcium (blood) Calcium phosphates cholecalciferol and calcitriol Cholesterol Down-regulation Feeding Gene expression High cholesterol diet High fat diet Hydroxylase Hypercalcemia Hypercholesterolemia Kidneys Kinases Lipid metabolism Liver liver Cyp7a1 Mice Nutrient deficiency Parathyroid Parathyroid hormone Phosphates Plasma Protein expression Protein kinase C Protein turnover Proteins renal Oat3 Rodents Vitamin D vitamin D receptor Vitamin D receptors Vitamin D3 vitamin D‐deficiency
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