Distribution of IL28B and IL10 polymorphisms as genetic predictors of treatment response in Pakistani HCV genotype 3 patients

There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pat...

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Veröffentlicht in:	Archives of virology 2018-04, Vol.163 (4), p.997-1008
Hauptverfasser:	Naeemi, Humaira, Aslam, Rabia, Raza, Syed Mohsin, Shahzad, Muhammad Aiman, Naz, Shagufta, Manzoor, Sobia, Khaliq, Saba
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Antiviral Agents - therapeutic use Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Case-Control Studies Cytokines Drug Therapy, Combination Female Gene Expression Gene Frequency Gene polymorphism Genotypes Haplotypes Hepacivirus - classification Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - immunology Humans Infectious Diseases Interferon Interferon-alpha - therapeutic use Interferons Interleukin 1 Interleukin 10 Interleukin-10 - genetics Interleukin-10 - immunology Interleukins - genetics Interleukins - immunology Male Medical Microbiology Middle Aged Original Article Pakistan Patients Polyethylene Glycols - therapeutic use Polymorphism Polymorphism, Single Nucleotide Population studies Prognosis Recombinant Proteins - therapeutic use Ribavirin Ribavirin - therapeutic use Single-nucleotide polymorphism Virology
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