Rosmarinic Acid Mitigates Lipopolysaccharide-Induced Neuroinflammatory Responses through the Inhibition of TLR4 and CD14 Expression and NF-κB and NLRP3 Inflammasome Activation

The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo ; however, the mechanism underlying its anti-neuroinflammatory activ...

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Veröffentlicht in:	Inflammation 2018-03, Vol.41 (2), p.732-740
Hauptverfasser:	Wei, Yicong, Chen, Jianxiong, Hu, Yonghong, Lu, Wei, Zhang, Xiaoqin, Wang, Ruiguo, Chu, Kedan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Biomedical and Life Sciences Biomedicine Brain Chemistry - drug effects CD11b antigen CD14 antigen Cinnamates - pharmacology Cyclooxygenase-2 Cytokines - drug effects Cytokines - metabolism Depsides - pharmacology Immunology Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation Mediators Interleukin 6 Internal Medicine JNK protein Lipopolysaccharide Receptors - antagonists & inhibitors Lipopolysaccharide Receptors - metabolism Lipopolysaccharides Lipopolysaccharides - adverse effects Macrophages Mice Microglia Neurodegenerative diseases Neuroprotection NF-kappa B - drug effects NF-κB protein Nitric-oxide synthase NLR Family, Pyrin Domain-Containing 3 Protein Original Article Pathology Pharmacology/Toxicology Phosphorylation Rheumatology Rosmarinic Acid TLR4 protein Toll-Like Receptor 4 - antagonists & inhibitors Toll-like receptors Tumor necrosis factor-α
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