Design and Synthesis of Building Blocks for PPII‐Helix Secondary‐Structure Mimetics: A Stereoselective Entry to 4‐Substituted 5‐Vinylprolines

In the course of our studies towards the synthesis of proline‐based secondary‐structure mimetics, we developed a straightforward methodology for the diastereoselective preparation of 4‐alkyl‐5‐vinyl‐substituted proline derivatives. Starting from N‐Boc‐protected tert‐butyl pyroglutamate, α‐alkylation...

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Veröffentlicht in:	European journal of organic chemistry 2018-01, Vol.2018 (4), p.455-460
Hauptverfasser:	Chiha, Slim, Soicke, Arne, Barone, Matthias, Müller, Matthias, Bruns, Judith, Opitz, Robert, Neudörfl, Jörg‐Martin, Kühne, Ronald, Schmalz, Hans‐Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Aluminum chloride Amides Amino acids Derivatives Metathesis Peptidomimetics Proline Protein–protein interactions Substitutes Synthesis
Online-Zugang:	Volltext
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