Chronic myeloid leukaemia

Summary Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CM...

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Veröffentlicht in:	The Lancet (British edition) 2007-07, Vol.370 (9584), p.342-350
Hauptverfasser:	Hehlmann, Rüdiger, Prof, Hochhaus, Andreas, Prof, Baccarani, Michele, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides Binding sites Biological and medical sciences Clinical trials General aspects Hematologic and hematopoietic diseases Humans Imatinib Mesylate Immunization Immunologic Factors - therapeutic use Interferon-alpha - therapeutic use Internal Medicine Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - physiopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medical treatment Older people Piperazines - adverse effects Piperazines - therapeutic use Prognosis Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyrimidines - adverse effects Pyrimidines - therapeutic use Randomized Controlled Trials as Topic Risk factors Signal transduction Stem Cell Transplantation Studies Success Survival Rate
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