Transferrin toxin but not transferrin receptor immunotoxin is influenced by free transferrin and iron saturation

Background Cytotoxic agents can be targeted successfully to cancer cells. The efficacy of such novel and potent anticancer strategies may be influenced by variables of iron metabolism. Methods The in vitro cytotoxicity against glioma cells of transferrin (Tf)‐based targeted toxins was compared wit...

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Veröffentlicht in:	European journal of clinical investigation 2002-03, Vol.32 (s1), p.61-69
Hauptverfasser:	Gosselaar, P. H., Van-Dijk, A. J. G., De-Gast, G. C., Polito, L., Bolognesi, A., Vooijs, W. C., Verheul, A. F. M., Krouwer, H. G. J., Marx, J. J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Binding, Competitive Biotin - metabolism Biotin - pharmacology Brain neoplasm Brain Neoplasms Glioblastoma Humans immunotoxin Immunotoxins - toxicity Iron - metabolism Iron - pharmacology Iron Radioisotopes Male Middle Aged N-Glycosyl Hydrolases Plant Proteins - analysis Plant Proteins - metabolism Plant Proteins - pharmacology Receptors, Transferrin - analysis Ribosome Inactivating Proteins, Type 1 Saporins therapy Transferrin - analysis Transferrin - metabolism Transferrin - toxicity transferrin receptor transferrin toxin Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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