Low-dose irradiation inhibits proliferation of the p53null type human prostate cancer cells through the ATM/p21 pathway

Low-dose ionizing radiation (LDIR) induces hormesis, exerts an adoptive effect on normal mammalian cells and stimulates cell proliferation; however, this effect is absent in cancer cells. Little is known on the molecular mechanisms underlying this differential response between normal and cancer cell...

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Veröffentlicht in:	International journal of molecular medicine 2018-01, Vol.41 (1), p.548-554
Hauptverfasser:	Li, Si-Jie, Liang, Xin-Yue, Li, Hai-Jun, Yang, Guo-Zi, Li, Wei, Li, Zhuo, Zhou, Lei, Wen, Xue, Yu, De-Hai, Cui, Jiu-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins - genetics Biotechnology Cancer therapies Cell culture Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - genetics Cell Proliferation - radiation effects Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-dependent kinases Deoxyribonucleic acid DNA DNA damage Gene Expression Regulation, Neoplastic - radiation effects Hormesis Hormesis - genetics Hormesis - radiation effects Humans Kinases Male Mutation Phosphorylation Prostate - pathology Prostate - radiation effects Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Proteins Radiation Dosage Radiation, Ionizing Signal Transduction - genetics Signal Transduction - radiation effects Studies Tumor Suppressor Protein p53 - genetics
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