Platelet-collagen interactions: membrane receptors and intracellular signalling pathways

Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet–collagen interaction support a ‘two‐site, two‐step’ model. Direct platelet binding to inte...

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Veröffentlicht in:	European journal of clinical investigation 1999-12, Vol.29 (12), p.1066-1076
Hauptverfasser:	ALBERIO, L, DALE, G. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Collagen Fundamental and applied biological sciences. Psychology glycoprotein VI integrin α2β1 platelet receptors signal transduction Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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container_title	European journal of clinical investigation
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creator	ALBERIO, L DALE, G. L
description	Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet–collagen interaction support a ‘two‐site, two‐step’ model. Direct platelet binding to integrin α2β1 mainly sustains adhesion and allows recognition of glycoprotein VI. The latter interaction is responsible for characteristic intracellular signalling events leading to p72Syk and PLCγ2 activation. The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.
doi_str_mv	10.1046/j.1365-2362.1999.00570.x
format	Article
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The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1046/j.1365-2362.1999.00570.x</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Collagen ; Fundamental and applied biological sciences. Psychology ; glycoprotein VI ; integrin α2β1 ; platelet ; receptors ; signal transduction ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>European journal of clinical investigation, 1999-12, Vol.29 (12), p.1066-1076</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.</description><subject>Biological and medical sciences</subject><subject>Collagen</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycoprotein VI</subject><subject>integrin α2β1</subject><subject>platelet</subject><subject>receptors</subject><subject>signal transduction</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqNkFFP2zAURq1pk-iA_xBNvCa7jp3ERnuZSmGVKtg0EIgX68a97dK5SbFT0f57HIrY655syed8sg5jCYeMgyy_rjIuyiLNRZlnXGudARQVZLsPbPT-8JGNALhMc13lR-xzCCsAUFzkI_bw02FPjvrUds7hktqkaXvyaPuma8N5sqZ17bGlxJOlTd_5kGA7H6DIkHNbhz4JzbJF55p2mWyw__OM-3DCPi3QBTp9O4_Z3eXkdvwjnd1cTcffZ6mVhYS0rKWCQtI8r6WFkqjUKOa6plppDZIUVjWArLTKi4WSKLWyFpUWqp5XUlbimH057G5897Sl0JtVt_XxN8HEHBy40GWE1AGyvgvB08JsfLNGvzcczJDRrMxQywy1Bk-b14xmF9Wzt30MFt0itrBN-OfnHIQSEft2wJ4bR_v_njeT8TReop4e9Cb0tHvX0f81ZSWqwtxfX5mL3-rx4vLhl7kWL7wVlYo</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>ALBERIO, L</creator><creator>DALE, G. 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source	Wiley Online Library - AutoHoldings Journals
subjects	Biological and medical sciences Collagen Fundamental and applied biological sciences. Psychology glycoprotein VI integrin α2β1 platelet receptors signal transduction Vertebrates: blood, hematopoietic organs, reticuloendothelial system
title	Platelet-collagen interactions: membrane receptors and intracellular signalling pathways
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