MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β-Catenin Signaling Pathway

Recently, microRNAs (miRNA) have been identified as novel regulators in Chondrosarcoma (CHS). This study was aimed to identify the roles of miR-129-5p-5p in regulation of SOX4 and Wnt/β-catenin signaling pathway, as well as cell proliferation and apoptosis in chondrosarcomas. Tissue samples were obt...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.42 (1), p.242-253
Hauptverfasser:	Zhang, Peng, Li, Jifeng, Song, Yuze, Wang , Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagomirs - metabolism Apoptosis beta Catenin - metabolism Bone cancer Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell cycle Cell growth Cell Line, Tumor Cell Movement Cell Proliferation Chemotherapy Chondrosarcoma Chondrosarcoma - metabolism Chondrosarcoma - pathology Cytokines Down-Regulation Epigenetics Esophagus Female Gastric cancer Gene expression Humans Liver cancer Lung cancer Male Melanoma Mice Mice, SCID MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-129-5p Prostate cancer Radiation therapy Retracted Paper Signal Transduction SOX4 SOXC Transcription Factors - antagonists & inhibitors SOXC Transcription Factors - genetics SOXC Transcription Factors - metabolism Transcription factors Up-Regulation Wnt Proteins - metabolism Wnt/β-catenin signaling pathway
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