MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma

Objective: The purpose of this study is to explore the effects of microRNA-29b (miR-29b) regulating MAPK/ERK and PI3K/Akt signaling pathways on angiogenesis in endometrial carcinoma (EC) by targeting VEGFA. Methods: Between February 2013 and April 2015, 126 EC patients admitted to the Second Affilia...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.41 (3), p.933-946
Hauptverfasser:	Chen, Hong-Xia, Xu, Xiao-Xia, Tan, Bu-Zhen, Zhang, Zhi, Zhou, Xiao-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Angiogenesis Animals Cancer therapies Cell Line, Tumor Disease Endometrial cancer Endometrial carcinoma Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery Endometrial Neoplasms - therapy Enzymes Female Flavonoids - pharmacology Gene expression Gene Expression Regulation, Neoplastic Genetic Vectors - chemistry Genetic Vectors - metabolism Humans Hypoxia Kinases Laboratory animals Lentivirus - genetics Lentivirus - metabolism MAPK/ERK signaling pathway Medical prognosis Melanoma Metastasis Mice Mice, Nude MicroRNA-29b MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Morphology Neoplasm Transplantation Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Neovascularization, Pathologic - surgery Neovascularization, Pathologic - therapy Original Paper Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt signaling pathway Plasmids Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transfection Tumorigenesis Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGFA Wortmannin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!