Rhabdomyolysis due to interaction of simvastatin with mibefradil

A case study of an 83-year-old woman with progressive immobilizing myopathy is presented. She suffered from rhabdomyolysis due to an interaction of simvastatin with mibefradil.

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Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 1998-06, Vol.351 (9120), p.1929-1930
Hauptverfasser:	Schmassmann-Suhijar, Diana, Bullingham, Roy, Gasser, Rodolfo, Schmutz, Jörg, Haefeli, Walter E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anticholesteremic Agents - adverse effects Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Benzimidazoles - adverse effects Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Biological and medical sciences Calcium Channel Blockers - adverse effects Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Case reports Case studies Drug Interactions Drug toxicity and drugs side effects treatment Female Humans In Vitro Techniques Medical disorders Medical research Medical sciences Mibefradil Microsomes, Liver - drug effects Pharmacology. Drug treatments Prescription drugs Rhabdomyolysis - chemically induced Simvastatin - adverse effects Simvastatin - pharmacology Simvastatin - therapeutic use Tetrahydronaphthalenes - adverse effects Tetrahydronaphthalenes - pharmacology Tetrahydronaphthalenes - therapeutic use Toxicity: nervous system and muscle
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Beschreibung
Zusammenfassung:	A case study of an 83-year-old woman with progressive immobilizing myopathy is presented. She suffered from rhabdomyolysis due to an interaction of simvastatin with mibefradil.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(05)78613-X