Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues du...
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| Veröffentlicht in: | The Lancet (British edition) 2000-04, Vol.355 (9214), p.1518-1519 |
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| container_issue | 9214 |
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| container_title | The Lancet (British edition) |
| container_volume | 355 |
| creator | Fasano, Alessio Not, Tarcisio Wang, Wenle Uzzau, Sergio Berti, Irene Tommasini, Alberto Goldblum, Simeon E |
| description | We identified zonulin, a novel human protein analogue to the
Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased. |
| doi_str_mv | 10.1016/S0140-6736(00)02169-3 |
| format | Article |
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Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(00)02169-3</identifier><identifier>PMID: 10801176</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Animals ; Biological and medical sciences ; Celiac Disease - metabolism ; Cholera Toxin - metabolism ; Cholera Toxin - pharmacology ; Disease ; Fetus ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Intestines - drug effects ; Macaca mulatta ; Medical research ; Medical sciences ; Other diseases. Semiology ; Permeability ; Permeability - drug effects ; Proteins ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Toxins</subject><ispartof>The Lancet (British edition), 2000-04, Vol.355 (9214), p.1518-1519</ispartof><rights>2000 Elsevier Ltd</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Apr 29, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-3101157d6c59016ea7227f2415c21d1d606a89e80308a009a2251ffa0d026f673</citedby><cites>FETCH-LOGICAL-c535t-3101157d6c59016ea7227f2415c21d1d606a89e80308a009a2251ffa0d026f673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199064348?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64394,72474</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1350662$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10801176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fasano, Alessio</creatorcontrib><creatorcontrib>Not, Tarcisio</creatorcontrib><creatorcontrib>Wang, Wenle</creatorcontrib><creatorcontrib>Uzzau, Sergio</creatorcontrib><creatorcontrib>Berti, Irene</creatorcontrib><creatorcontrib>Tommasini, Alberto</creatorcontrib><creatorcontrib>Goldblum, Simeon E</creatorcontrib><title>Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>We identified zonulin, a novel human protein analogue to the
Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Celiac Disease - metabolism</subject><subject>Cholera Toxin - metabolism</subject><subject>Cholera Toxin - pharmacology</subject><subject>Disease</subject><subject>Fetus</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intestines - drug effects</subject><subject>Macaca mulatta</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Permeability</subject><subject>Permeability - drug effects</subject><subject>Proteins</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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discovered modulator of intestinal permeability, and its expression in coeliac disease</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2000-04-29</date><risdate>2000</risdate><volume>355</volume><issue>9214</issue><spage>1518</spage><epage>1519</epage><pages>1518-1519</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>We identified zonulin, a novel human protein analogue to the
Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>10801176</pmid><doi>10.1016/S0140-6736(00)02169-3</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2000-04, Vol.355 (9214), p.1518-1519 |
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| subjects | Adult Animals Biological and medical sciences Celiac Disease - metabolism Cholera Toxin - metabolism Cholera Toxin - pharmacology Disease Fetus Gastroenterology. Liver. Pancreas. Abdomen Humans Intestines - drug effects Macaca mulatta Medical research Medical sciences Other diseases. Semiology Permeability Permeability - drug effects Proteins Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Toxins |
| title | Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease |
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