Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene
Summary Background An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT 2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association betw...
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| Veröffentlicht in: | The Lancet (British edition) 1996-05, Vol.347 (9011), p.1294-1296 |
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| creator | European Multicentre Association Study of Schizophrenia (EMASS) Group Williams, J. Spurlock, G. McGuffin, P. Owen, M.J. Mallet, J. Nöthen, M.M. Gill, M. Aschauer, H. Nylander, P-O. Macciardi, F. |
| description | Summary
Background An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT
2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association between schizophrenia and this variant of the 5-HT
2a-receptor gene in a large multicentre study.
Methods Seven countries recruited 1210 participants: 571 white schizophrenic patients and 639 ethnically matched controls. All patients had a diagnosis of schizophrenia or schizoaffective disorder. High-molecular-weight DNA was isolated from lymphocytes. PCR amplification and restriction enzyme digestion was used to examine sequence variation of the 5-HT
2a-receptor gene. Genotypes
1/1, 1/2,and
2/2 were assigned. Woolf's method was used to look for an association between schizophrenia and allele 2 and the
2/2genotype.
Findings We found a significant overall association between schizophrenia and allele 2 with an odds ratio of 1·3 (95% Cl 1·1-1·53, p=0·003). No evidence for heterogeneity was observed between samples. We found a highly significant excess of the
1-2/2-2genotypes in schizophrenia (p=0·008) with a relative risk of 1·7 (1·22-2·36) and an attributable fraction of 0·35.
Interpretation Our findings suggest that the gene for 5-HT
2a-receptor, or a locus in linkage disequilibrium with it, confers susceptibility to schizophrenia. Allele 2 is common in the population and it is, therefore, likely that this variant, or a nearby polymorphism, may affect a significant proportion of schizophrenic patients. |
| doi_str_mv | 10.1016/S0140-6736(96)90939-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_199053142</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673696909393</els_id><sourcerecordid>9660954</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-803f41eb1dcdb32881b867390fe6da618f61f722f9c7b45fe021192f9d614f593</originalsourceid><addsrcrecordid>eNqFkM9rFDEUgINYcK3-CUIQD3oYzZtkMpOTlEVboeChLXgLmcyLk7KbjElanf71Zt3Sq_Dg8eB7vz5C3gD7CAzkpysGgjWy5_K9kh8UU1w1_BnZgOhF04n-x3OyeUJekJc53zLGhGTdhviznKP1pvgY6IjlN2Kg2c7-IS5zwuANNWGi18DaLV3ibt3HtMw-72l0tMxIu2ZepxT_rCWtSzF7H5CWdUHamiahxaXERH9iwFfkxJldxteP-ZTcfP1yvb1oLr-ff9ueXTaWS16agXEnAEeY7DTydhhgHOrdijmUk5EwOAmub1unbD-KziFrAVQtJwnCdYqfkrfHuUuKv-4wF30b71KoKzUoxToOoq1Qd4RsijkndHpJfm_SqoHpg1T9T6o-GNOqxkGq5rXv3eNwk63ZuWSC9fmpmbN-4MNQsc9HDOuj9x6TztZjsDj56qToKfr_LPoLGo6L3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199053142</pqid></control><display><type>article</type><title>Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene</title><source>Business Source Complete</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>European Multicentre Association Study of Schizophrenia (EMASS) Group ; Williams, J. ; Spurlock, G. ; McGuffin, P. ; Owen, M.J. ; Mallet, J. ; Nöthen, M.M. ; Gill, M. ; Aschauer, H. ; Nylander, P-O. ; Macciardi, F.</creator><creatorcontrib>European Multicentre Association Study of Schizophrenia (EMASS) Group ; Williams, J. ; Spurlock, G. ; McGuffin, P. ; Owen, M.J. ; Mallet, J. ; Nöthen, M.M. ; Gill, M. ; Aschauer, H. ; Nylander, P-O. ; Macciardi, F. ; European Multicentre Association Study of Schizophrenia (EMASS) Group</creatorcontrib><description>Summary
Background An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT
2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association between schizophrenia and this variant of the 5-HT
2a-receptor gene in a large multicentre study.
Methods Seven countries recruited 1210 participants: 571 white schizophrenic patients and 639 ethnically matched controls. All patients had a diagnosis of schizophrenia or schizoaffective disorder. High-molecular-weight DNA was isolated from lymphocytes. PCR amplification and restriction enzyme digestion was used to examine sequence variation of the 5-HT
2a-receptor gene. Genotypes
1/1, 1/2,and
2/2 were assigned. Woolf's method was used to look for an association between schizophrenia and allele 2 and the
2/2genotype.
Findings We found a significant overall association between schizophrenia and allele 2 with an odds ratio of 1·3 (95% Cl 1·1-1·53, p=0·003). No evidence for heterogeneity was observed between samples. We found a highly significant excess of the
1-2/2-2genotypes in schizophrenia (p=0·008) with a relative risk of 1·7 (1·22-2·36) and an attributable fraction of 0·35.
Interpretation Our findings suggest that the gene for 5-HT
2a-receptor, or a locus in linkage disequilibrium with it, confers susceptibility to schizophrenia. Allele 2 is common in the population and it is, therefore, likely that this variant, or a nearby polymorphism, may affect a significant proportion of schizophrenic patients.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(96)90939-3</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult and adolescent clinical studies ; Biological and medical sciences ; Genetics ; Genotypes ; Heterogeneity ; Lymphocytes ; Medical sciences ; Mental disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia</subject><ispartof>The Lancet (British edition), 1996-05, Vol.347 (9011), p.1294-1296</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Lancet Ltd. May 11, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-803f41eb1dcdb32881b867390fe6da618f61f722f9c7b45fe021192f9d614f593</citedby><cites>FETCH-LOGICAL-c363t-803f41eb1dcdb32881b867390fe6da618f61f722f9c7b45fe021192f9d614f593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199053142?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3078388$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>European Multicentre Association Study of Schizophrenia (EMASS) Group</creatorcontrib><creatorcontrib>Williams, J.</creatorcontrib><creatorcontrib>Spurlock, G.</creatorcontrib><creatorcontrib>McGuffin, P.</creatorcontrib><creatorcontrib>Owen, M.J.</creatorcontrib><creatorcontrib>Mallet, J.</creatorcontrib><creatorcontrib>Nöthen, M.M.</creatorcontrib><creatorcontrib>Gill, M.</creatorcontrib><creatorcontrib>Aschauer, H.</creatorcontrib><creatorcontrib>Nylander, P-O.</creatorcontrib><creatorcontrib>Macciardi, F.</creatorcontrib><creatorcontrib>European Multicentre Association Study of Schizophrenia (EMASS) Group</creatorcontrib><title>Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene</title><title>The Lancet (British edition)</title><description>Summary
Background An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT
2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association between schizophrenia and this variant of the 5-HT
2a-receptor gene in a large multicentre study.
Methods Seven countries recruited 1210 participants: 571 white schizophrenic patients and 639 ethnically matched controls. All patients had a diagnosis of schizophrenia or schizoaffective disorder. High-molecular-weight DNA was isolated from lymphocytes. PCR amplification and restriction enzyme digestion was used to examine sequence variation of the 5-HT
2a-receptor gene. Genotypes
1/1, 1/2,and
2/2 were assigned. Woolf's method was used to look for an association between schizophrenia and allele 2 and the
2/2genotype.
Findings We found a significant overall association between schizophrenia and allele 2 with an odds ratio of 1·3 (95% Cl 1·1-1·53, p=0·003). No evidence for heterogeneity was observed between samples. We found a highly significant excess of the
1-2/2-2genotypes in schizophrenia (p=0·008) with a relative risk of 1·7 (1·22-2·36) and an attributable fraction of 0·35.
Interpretation Our findings suggest that the gene for 5-HT
2a-receptor, or a locus in linkage disequilibrium with it, confers susceptibility to schizophrenia. Allele 2 is common in the population and it is, therefore, likely that this variant, or a nearby polymorphism, may affect a significant proportion of schizophrenic patients.</description><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Genetics</subject><subject>Genotypes</subject><subject>Heterogeneity</subject><subject>Lymphocytes</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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J.</au><au>Spurlock, G.</au><au>McGuffin, P.</au><au>Owen, M.J.</au><au>Mallet, J.</au><au>Nöthen, M.M.</au><au>Gill, M.</au><au>Aschauer, H.</au><au>Nylander, P-O.</au><au>Macciardi, F.</au><aucorp>European Multicentre Association Study of Schizophrenia (EMASS) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene</atitle><jtitle>The Lancet (British edition)</jtitle><date>1996-05-11</date><risdate>1996</risdate><volume>347</volume><issue>9011</issue><spage>1294</spage><epage>1296</epage><pages>1294-1296</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary
Background An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT
2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association between schizophrenia and this variant of the 5-HT
2a-receptor gene in a large multicentre study.
Methods Seven countries recruited 1210 participants: 571 white schizophrenic patients and 639 ethnically matched controls. All patients had a diagnosis of schizophrenia or schizoaffective disorder. High-molecular-weight DNA was isolated from lymphocytes. PCR amplification and restriction enzyme digestion was used to examine sequence variation of the 5-HT
2a-receptor gene. Genotypes
1/1, 1/2,and
2/2 were assigned. Woolf's method was used to look for an association between schizophrenia and allele 2 and the
2/2genotype.
Findings We found a significant overall association between schizophrenia and allele 2 with an odds ratio of 1·3 (95% Cl 1·1-1·53, p=0·003). No evidence for heterogeneity was observed between samples. We found a highly significant excess of the
1-2/2-2genotypes in schizophrenia (p=0·008) with a relative risk of 1·7 (1·22-2·36) and an attributable fraction of 0·35.
Interpretation Our findings suggest that the gene for 5-HT
2a-receptor, or a locus in linkage disequilibrium with it, confers susceptibility to schizophrenia. Allele 2 is common in the population and it is, therefore, likely that this variant, or a nearby polymorphism, may affect a significant proportion of schizophrenic patients.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0140-6736(96)90939-3</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1996-05, Vol.347 (9011), p.1294-1296 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_journals_199053142 |
| source | Business Source Complete; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adult and adolescent clinical studies Biological and medical sciences Genetics Genotypes Heterogeneity Lymphocytes Medical sciences Mental disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia |
| title | Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene |
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