Characterization of CD127-ￂ CD25++ Treg from human colostrum
Problem Breastfeeding's influence on the tolerance to environmental antigens is essential for short- and long-term homeostasis for children. Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population. Method of study Frequencies...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2018-02, Vol.79 (2) |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 79 |
| creator | Cerbulo-Vazquez, Arturo Hernandez-Pelaez, Graciela Arriaga-Pizano, Lourdes A Bautista-Perez, Paulina Romero-Venado, Jannett Flores-Gonzalez, Julio C Figueroa-Damian, Ricardo Soriano-Becerril, Diana Mancilla-Herrera, Ismael |
| description | Problem Breastfeeding's influence on the tolerance to environmental antigens is essential for short- and long-term homeostasis for children. Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population. Method of study Frequencies of CD127- CD25++ Treg and levels of immunoregulatory-associated cell markers were determined in colostrum and were compared with autologous blood cells. In addition, we evaluated whether the birth conditions can affect these features. Results Higher frequencies of CD127 -CD25++ Treg cells expressing Foxp3 and CD45RO were observed in the colostrum. The cells' CD25, CD152, CD279, and TGF-[beta] expression levels were greater than those in autologous blood cells. In addition, the CD279 and TGF-[beta] expressions of colostrum CD127- CD25++ Treg cells were influenced by gestational age and delivery mode. Conclusion The higher proportion of these cells with a function-associated phenotype may reflect certain tolerogenic effects of breastmilk on newborns and infants, contributing to immune system homeostasis. |
| doi_str_mv | 10.1111/aji.12806 |
| format | Article |
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Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population. Method of study Frequencies of CD127- CD25++ Treg and levels of immunoregulatory-associated cell markers were determined in colostrum and were compared with autologous blood cells. In addition, we evaluated whether the birth conditions can affect these features. Results Higher frequencies of CD127 -CD25++ Treg cells expressing Foxp3 and CD45RO were observed in the colostrum. The cells' CD25, CD152, CD279, and TGF-[beta] expression levels were greater than those in autologous blood cells. In addition, the CD279 and TGF-[beta] expressions of colostrum CD127- CD25++ Treg cells were influenced by gestational age and delivery mode. Conclusion The higher proportion of these cells with a function-associated phenotype may reflect certain tolerogenic effects of breastmilk on newborns and infants, contributing to immune system homeostasis.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12806</identifier><language>eng</language><publisher>New Haven: Wiley Subscription Services, Inc</publisher><subject>Antigens ; Breast feeding ; CD25 antigen ; Children ; Colostrum ; CTLA-4 protein ; Foxp3 protein ; Gestational age ; Homeostasis ; Immune system ; Immunological tolerance ; Immunoregulation ; Infants ; Leukocytes ; Lymphocytes T ; Neonates ; Population studies</subject><ispartof>American journal of reproductive immunology (1989), 2018-02, Vol.79 (2)</ispartof><rights>Copyright © 2018 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Cerbulo-Vazquez, Arturo</creatorcontrib><creatorcontrib>Hernandez-Pelaez, Graciela</creatorcontrib><creatorcontrib>Arriaga-Pizano, Lourdes A</creatorcontrib><creatorcontrib>Bautista-Perez, Paulina</creatorcontrib><creatorcontrib>Romero-Venado, Jannett</creatorcontrib><creatorcontrib>Flores-Gonzalez, Julio C</creatorcontrib><creatorcontrib>Figueroa-Damian, Ricardo</creatorcontrib><creatorcontrib>Soriano-Becerril, Diana</creatorcontrib><creatorcontrib>Mancilla-Herrera, Ismael</creatorcontrib><title>Characterization of CD127-ￂ CD25++ Treg from human colostrum</title><title>American journal of reproductive immunology (1989)</title><description>Problem Breastfeeding's influence on the tolerance to environmental antigens is essential for short- and long-term homeostasis for children. Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population. Method of study Frequencies of CD127- CD25++ Treg and levels of immunoregulatory-associated cell markers were determined in colostrum and were compared with autologous blood cells. In addition, we evaluated whether the birth conditions can affect these features. Results Higher frequencies of CD127 -CD25++ Treg cells expressing Foxp3 and CD45RO were observed in the colostrum. The cells' CD25, CD152, CD279, and TGF-[beta] expression levels were greater than those in autologous blood cells. In addition, the CD279 and TGF-[beta] expressions of colostrum CD127- CD25++ Treg cells were influenced by gestational age and delivery mode. Conclusion The higher proportion of these cells with a function-associated phenotype may reflect certain tolerogenic effects of breastmilk on newborns and infants, contributing to immune system homeostasis.</description><subject>Antigens</subject><subject>Breast feeding</subject><subject>CD25 antigen</subject><subject>Children</subject><subject>Colostrum</subject><subject>CTLA-4 protein</subject><subject>Foxp3 protein</subject><subject>Gestational age</subject><subject>Homeostasis</subject><subject>Immune system</subject><subject>Immunological tolerance</subject><subject>Immunoregulation</subject><subject>Infants</subject><subject>Leukocytes</subject><subject>Lymphocytes T</subject><subject>Neonates</subject><subject>Population studies</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpjYBA0NNAzBAL9xKxMPUMjCwMzJgZOQzMDA10DC0tzFiDbwMRM19zEwIKDgau4OMvAAChubM7JYOeckViUmFySWpRZlViSmZ-nkJ-m4OxiaGSu-35_E5BlZKqtrRBSlJqukFaUn6uQUZqbmKeQnJ-TX1xSVJrLw8CalphTnMoLpbkZlN1cQ5w9dAuK8gtLU4tL4rPyS4vygFLxhpaWBiZGphbGRsbEqQIAWa88oA</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Cerbulo-Vazquez, Arturo</creator><creator>Hernandez-Pelaez, Graciela</creator><creator>Arriaga-Pizano, Lourdes A</creator><creator>Bautista-Perez, Paulina</creator><creator>Romero-Venado, Jannett</creator><creator>Flores-Gonzalez, Julio C</creator><creator>Figueroa-Damian, Ricardo</creator><creator>Soriano-Becerril, Diana</creator><creator>Mancilla-Herrera, Ismael</creator><general>Wiley Subscription Services, Inc</general><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20180201</creationdate><title>Characterization of CD127-ￂ CD25++ Treg from human colostrum</title><author>Cerbulo-Vazquez, Arturo ; Hernandez-Pelaez, Graciela ; Arriaga-Pizano, Lourdes A ; Bautista-Perez, Paulina ; Romero-Venado, Jannett ; Flores-Gonzalez, Julio C ; Figueroa-Damian, Ricardo ; Soriano-Becerril, Diana ; Mancilla-Herrera, Ismael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_19904258323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antigens</topic><topic>Breast feeding</topic><topic>CD25 antigen</topic><topic>Children</topic><topic>Colostrum</topic><topic>CTLA-4 protein</topic><topic>Foxp3 protein</topic><topic>Gestational age</topic><topic>Homeostasis</topic><topic>Immune system</topic><topic>Immunological tolerance</topic><topic>Immunoregulation</topic><topic>Infants</topic><topic>Leukocytes</topic><topic>Lymphocytes T</topic><topic>Neonates</topic><topic>Population studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cerbulo-Vazquez, Arturo</creatorcontrib><creatorcontrib>Hernandez-Pelaez, Graciela</creatorcontrib><creatorcontrib>Arriaga-Pizano, Lourdes A</creatorcontrib><creatorcontrib>Bautista-Perez, Paulina</creatorcontrib><creatorcontrib>Romero-Venado, Jannett</creatorcontrib><creatorcontrib>Flores-Gonzalez, Julio C</creatorcontrib><creatorcontrib>Figueroa-Damian, Ricardo</creatorcontrib><creatorcontrib>Soriano-Becerril, Diana</creatorcontrib><creatorcontrib>Mancilla-Herrera, Ismael</creatorcontrib><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cerbulo-Vazquez, Arturo</au><au>Hernandez-Pelaez, Graciela</au><au>Arriaga-Pizano, Lourdes A</au><au>Bautista-Perez, Paulina</au><au>Romero-Venado, Jannett</au><au>Flores-Gonzalez, Julio C</au><au>Figueroa-Damian, Ricardo</au><au>Soriano-Becerril, Diana</au><au>Mancilla-Herrera, Ismael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of CD127-ￂ CD25++ Treg from human colostrum</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><date>2018-02-01</date><risdate>2018</risdate><volume>79</volume><issue>2</issue><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem Breastfeeding's influence on the tolerance to environmental antigens is essential for short- and long-term homeostasis for children. Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population. Method of study Frequencies of CD127- CD25++ Treg and levels of immunoregulatory-associated cell markers were determined in colostrum and were compared with autologous blood cells. In addition, we evaluated whether the birth conditions can affect these features. Results Higher frequencies of CD127 -CD25++ Treg cells expressing Foxp3 and CD45RO were observed in the colostrum. The cells' CD25, CD152, CD279, and TGF-[beta] expression levels were greater than those in autologous blood cells. In addition, the CD279 and TGF-[beta] expressions of colostrum CD127- CD25++ Treg cells were influenced by gestational age and delivery mode. Conclusion The higher proportion of these cells with a function-associated phenotype may reflect certain tolerogenic effects of breastmilk on newborns and infants, contributing to immune system homeostasis.</abstract><cop>New Haven</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/aji.12806</doi></addata></record> |
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| subjects | Antigens Breast feeding CD25 antigen Children Colostrum CTLA-4 protein Foxp3 protein Gestational age Homeostasis Immune system Immunological tolerance Immunoregulation Infants Leukocytes Lymphocytes T Neonates Population studies |
| title | Characterization of CD127-ￂ CD25++ Treg from human colostrum |
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