Population Pharmacokinetics and Bayesian Estimators for Refined Dose Adjustment of a New Tacrolimus Formulation in Kidney and Liver Transplant Patients

Background and Objectives A new once-daily formulation of tacrolimus (Envarsus ® ) has recently been developed, with alleged different pharmacokinetics from previous tacrolimus formulations. The objectives of this study were to develop population pharmacokinetic models and Bayesian estimators based...

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Veröffentlicht in:	Clinical pharmacokinetics 2017-12, Vol.56 (12), p.1491-1498
Hauptverfasser:	Woillard, Jean-Baptiste, Debord, Jean, Monchaud, Caroline, Saint-Marcoux, Franck, Marquet, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Algorithms Area Under Curve Bayes Theorem Chromatography Clinical trials Cystic fibrosis Datasets Dose-Response Relationship, Drug Drug dosages Female Health risk assessment Humans Hypotheses Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Internal Medicine Kidney Transplantation - methods Liver Liver Transplantation - methods Liver transplants Male Mass spectrometry Medicine Medicine & Public Health Middle Aged Models, Biological Monte Carlo simulation Original Research Article Pharmaceuticals Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Population Prospective Studies Scientific imaging Tacrolimus - administration & dosage Tacrolimus - pharmacokinetics Transplants & implants Young Adult
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