Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components
Concern about the risks of cardiovascular illness in women using combined oral contraceptives (OC) containing the progestagens desogestrel and gestodene prompted two studies of data from the UK General Practice Research Database. We compared the risks of certain cardiovascular illnesses in otherwise...
Gespeichert in:
Veröffentlicht in: | The Lancet (British edition) 1995-12, Vol.346 (8990), p.1589-1593 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1593 |
---|---|
container_issue | 8990 |
container_start_page | 1589 |
container_title | The Lancet (British edition) |
container_volume | 346 |
creator | JICK, H JICK, S. S GUREWICH, V MYERS, M. W VASILAKIS, C |
description | Concern about the risks of cardiovascular illness in women using combined oral contraceptives (OC) containing the progestagens desogestrel and gestodene prompted two studies of data from the UK General Practice Research Database. We compared the risks of certain cardiovascular illnesses in otherwise healthy women exposed to one of three OCs containing < 35 micrograms oestrogen plus levonorgestrel, desogestrel, or gestodene. In the first study, based on some 470 general practices, there were 15 cases of unexpected idiopathic cardiovascular death among 303,470 women who were current users of one of the study OCs. The estimated incidence rates were 8/184,536 (4.3 per 100,000) woman-years at risk for users of combined OCs containing levonorgestrel, 2/135,567 (1.5 per 100,000) for desogestrel users, and 5/105,201 (4.8 per 100,000) for gestodene users. The relative risk (RR) estimates were 0.4 (95% CI 0.1-2.1) and 1.4 (CI 0.5-4.5) for desogestrel and gestodene, respectively, compared with levonorgestrel. In the second study, derived from some 370 general practices, there were 80 cases of nonfatal venous thromboembolism (VTE) in a cohort of 238,130 otherwise healthy women. The incidence rates of VTE per 100,000 woman-years at risk were 16.1 for levonorgestrel users, 29.3 for desogestrel, and 28.1 for gestodene. The adjusted RR estimates from the cohort analysis were 1.9 (1.1-3.2) and 1.8 (1.0-3.2) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. In a nested case-control analysis the adjusted matched RR estimates were 2.2 (1.1-4.4) and 2.1 (1.0-4.4) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. The excess risk for nonfatal VTE associated with the new generation of combined OCs containing low-dose oestrogen and the progestagens desogestrel or gestodene compared with levonorgestrel is estimated to be 16 per 100,000 woman-years. |
doi_str_mv | 10.1016/S0140-6736(95)91928-7 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_199032486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8703544</sourcerecordid><originalsourceid>FETCH-LOGICAL-g219t-cf61d65d63216e423105cf9fce0d84fd547eaba68c150a30cb6577d075f934aa3</originalsourceid><addsrcrecordid>eNo9kNtKAzEQhoMoWquPIATxQi9Wk91stnspxRMUBA_gXZnmUFN3kzXZrfgePrAjll4Mw8x8c_oJOeHskjMur54ZFyyTVSHP6_Ki5nU-yaodMuKiElkpqrddMtoiB-QwpRVjTEhW7pP9qmQMbUR-nlz6oMFSp13ooH93iiqIGKwhqaGBSLXBNAWvqQ_eQg8NXRsfhkT79xjaRTBojUstdZ5-hdZ4OiTnlzRERFXwfQRlut6tTaJfDmdpZ62Jf0gXw9KkHpbYpELbBW98n47InoUmmeONH5PX25uX6X02e7x7mF7PsmXO6z5TVnItSy2LnEsj8oKzUtnaKsP0RFiNIhhYgJwoXjIomFrIsqo0Pm7rQgAUY3L6PxfP-BzwjvkqDNHjyjmva1bkYiIROtlAw6I1et5F10L8nm8kxPrZpo6CQWMjeOXSFstxFWpe_ALsg4UX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199032486</pqid></control><display><type>article</type><title>Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components</title><source>MEDLINE</source><source>EBSCOhost Business Source Complete</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>JICK, H ; JICK, S. S ; GUREWICH, V ; MYERS, M. W ; VASILAKIS, C</creator><creatorcontrib>JICK, H ; JICK, S. S ; GUREWICH, V ; MYERS, M. W ; VASILAKIS, C</creatorcontrib><description>Concern about the risks of cardiovascular illness in women using combined oral contraceptives (OC) containing the progestagens desogestrel and gestodene prompted two studies of data from the UK General Practice Research Database. We compared the risks of certain cardiovascular illnesses in otherwise healthy women exposed to one of three OCs containing < 35 micrograms oestrogen plus levonorgestrel, desogestrel, or gestodene. In the first study, based on some 470 general practices, there were 15 cases of unexpected idiopathic cardiovascular death among 303,470 women who were current users of one of the study OCs. The estimated incidence rates were 8/184,536 (4.3 per 100,000) woman-years at risk for users of combined OCs containing levonorgestrel, 2/135,567 (1.5 per 100,000) for desogestrel users, and 5/105,201 (4.8 per 100,000) for gestodene users. The relative risk (RR) estimates were 0.4 (95% CI 0.1-2.1) and 1.4 (CI 0.5-4.5) for desogestrel and gestodene, respectively, compared with levonorgestrel. In the second study, derived from some 370 general practices, there were 80 cases of nonfatal venous thromboembolism (VTE) in a cohort of 238,130 otherwise healthy women. The incidence rates of VTE per 100,000 woman-years at risk were 16.1 for levonorgestrel users, 29.3 for desogestrel, and 28.1 for gestodene. The adjusted RR estimates from the cohort analysis were 1.9 (1.1-3.2) and 1.8 (1.0-3.2) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. In a nested case-control analysis the adjusted matched RR estimates were 2.2 (1.1-4.4) and 2.1 (1.0-4.4) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. The excess risk for nonfatal VTE associated with the new generation of combined OCs containing low-dose oestrogen and the progestagens desogestrel or gestodene compared with levonorgestrel is estimated to be 16 per 100,000 woman-years.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(95)91928-7</identifier><identifier>PMID: 7500750</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Lancet</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; Cardiovascular disease ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - mortality ; Case-Control Studies ; Cohort Studies ; Contraceptives ; Contraceptives, Oral, Combined - adverse effects ; Desogestrel - adverse effects ; Drug toxicity and drugs side effects treatment ; Estrogens ; Ethinyl Estradiol - administration & dosage ; Female ; Health risks ; Humans ; Incidence ; Levonorgestrel - adverse effects ; Medical research ; Medical sciences ; Norpregnenes - adverse effects ; Pharmacology. Drug treatments ; Progestins - adverse effects ; Risk Factors ; Thromboembolism ; Thromboembolism - chemically induced ; Thromboembolism - epidemiology ; Toxicity: cardiovascular system ; Women</subject><ispartof>The Lancet (British edition), 1995-12, Vol.346 (8990), p.1589-1593</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Dec 16, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199032486?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,64392,64396,72476</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2934605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7500750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JICK, H</creatorcontrib><creatorcontrib>JICK, S. S</creatorcontrib><creatorcontrib>GUREWICH, V</creatorcontrib><creatorcontrib>MYERS, M. W</creatorcontrib><creatorcontrib>VASILAKIS, C</creatorcontrib><title>Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Concern about the risks of cardiovascular illness in women using combined oral contraceptives (OC) containing the progestagens desogestrel and gestodene prompted two studies of data from the UK General Practice Research Database. We compared the risks of certain cardiovascular illnesses in otherwise healthy women exposed to one of three OCs containing < 35 micrograms oestrogen plus levonorgestrel, desogestrel, or gestodene. In the first study, based on some 470 general practices, there were 15 cases of unexpected idiopathic cardiovascular death among 303,470 women who were current users of one of the study OCs. The estimated incidence rates were 8/184,536 (4.3 per 100,000) woman-years at risk for users of combined OCs containing levonorgestrel, 2/135,567 (1.5 per 100,000) for desogestrel users, and 5/105,201 (4.8 per 100,000) for gestodene users. The relative risk (RR) estimates were 0.4 (95% CI 0.1-2.1) and 1.4 (CI 0.5-4.5) for desogestrel and gestodene, respectively, compared with levonorgestrel. In the second study, derived from some 370 general practices, there were 80 cases of nonfatal venous thromboembolism (VTE) in a cohort of 238,130 otherwise healthy women. The incidence rates of VTE per 100,000 woman-years at risk were 16.1 for levonorgestrel users, 29.3 for desogestrel, and 28.1 for gestodene. The adjusted RR estimates from the cohort analysis were 1.9 (1.1-3.2) and 1.8 (1.0-3.2) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. In a nested case-control analysis the adjusted matched RR estimates were 2.2 (1.1-4.4) and 2.1 (1.0-4.4) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. The excess risk for nonfatal VTE associated with the new generation of combined OCs containing low-dose oestrogen and the progestagens desogestrel or gestodene compared with levonorgestrel is estimated to be 16 per 100,000 woman-years.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - chemically induced</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Contraceptives</subject><subject>Contraceptives, Oral, Combined - adverse effects</subject><subject>Desogestrel - adverse effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Estrogens</subject><subject>Ethinyl Estradiol - administration & dosage</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Incidence</subject><subject>Levonorgestrel - adverse effects</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Norpregnenes - adverse effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Progestins - adverse effects</subject><subject>Risk Factors</subject><subject>Thromboembolism</subject><subject>Thromboembolism - chemically induced</subject><subject>Thromboembolism - epidemiology</subject><subject>Toxicity: cardiovascular system</subject><subject>Women</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNo9kNtKAzEQhoMoWquPIATxQi9Wk91stnspxRMUBA_gXZnmUFN3kzXZrfgePrAjll4Mw8x8c_oJOeHskjMur54ZFyyTVSHP6_Ki5nU-yaodMuKiElkpqrddMtoiB-QwpRVjTEhW7pP9qmQMbUR-nlz6oMFSp13ooH93iiqIGKwhqaGBSLXBNAWvqQ_eQg8NXRsfhkT79xjaRTBojUstdZ5-hdZ4OiTnlzRERFXwfQRlut6tTaJfDmdpZ62Jf0gXw9KkHpbYpELbBW98n47InoUmmeONH5PX25uX6X02e7x7mF7PsmXO6z5TVnItSy2LnEsj8oKzUtnaKsP0RFiNIhhYgJwoXjIomFrIsqo0Pm7rQgAUY3L6PxfP-BzwjvkqDNHjyjmva1bkYiIROtlAw6I1et5F10L8nm8kxPrZpo6CQWMjeOXSFstxFWpe_ALsg4UX</recordid><startdate>19951216</startdate><enddate>19951216</enddate><creator>JICK, H</creator><creator>JICK, S. S</creator><creator>GUREWICH, V</creator><creator>MYERS, M. W</creator><creator>VASILAKIS, C</creator><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>19951216</creationdate><title>Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components</title><author>JICK, H ; JICK, S. S ; GUREWICH, V ; MYERS, M. W ; VASILAKIS, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g219t-cf61d65d63216e423105cf9fce0d84fd547eaba68c150a30cb6577d075f934aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - chemically induced</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Contraceptives</topic><topic>Contraceptives, Oral, Combined - adverse effects</topic><topic>Desogestrel - adverse effects</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Estrogens</topic><topic>Ethinyl Estradiol - administration & dosage</topic><topic>Female</topic><topic>Health risks</topic><topic>Humans</topic><topic>Incidence</topic><topic>Levonorgestrel - adverse effects</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Norpregnenes - adverse effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Progestins - adverse effects</topic><topic>Risk Factors</topic><topic>Thromboembolism</topic><topic>Thromboembolism - chemically induced</topic><topic>Thromboembolism - epidemiology</topic><topic>Toxicity: cardiovascular system</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JICK, H</creatorcontrib><creatorcontrib>JICK, S. S</creatorcontrib><creatorcontrib>GUREWICH, V</creatorcontrib><creatorcontrib>MYERS, M. W</creatorcontrib><creatorcontrib>VASILAKIS, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JICK, H</au><au>JICK, S. S</au><au>GUREWICH, V</au><au>MYERS, M. W</au><au>VASILAKIS, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1995-12-16</date><risdate>1995</risdate><volume>346</volume><issue>8990</issue><spage>1589</spage><epage>1593</epage><pages>1589-1593</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Concern about the risks of cardiovascular illness in women using combined oral contraceptives (OC) containing the progestagens desogestrel and gestodene prompted two studies of data from the UK General Practice Research Database. We compared the risks of certain cardiovascular illnesses in otherwise healthy women exposed to one of three OCs containing < 35 micrograms oestrogen plus levonorgestrel, desogestrel, or gestodene. In the first study, based on some 470 general practices, there were 15 cases of unexpected idiopathic cardiovascular death among 303,470 women who were current users of one of the study OCs. The estimated incidence rates were 8/184,536 (4.3 per 100,000) woman-years at risk for users of combined OCs containing levonorgestrel, 2/135,567 (1.5 per 100,000) for desogestrel users, and 5/105,201 (4.8 per 100,000) for gestodene users. The relative risk (RR) estimates were 0.4 (95% CI 0.1-2.1) and 1.4 (CI 0.5-4.5) for desogestrel and gestodene, respectively, compared with levonorgestrel. In the second study, derived from some 370 general practices, there were 80 cases of nonfatal venous thromboembolism (VTE) in a cohort of 238,130 otherwise healthy women. The incidence rates of VTE per 100,000 woman-years at risk were 16.1 for levonorgestrel users, 29.3 for desogestrel, and 28.1 for gestodene. The adjusted RR estimates from the cohort analysis were 1.9 (1.1-3.2) and 1.8 (1.0-3.2) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. In a nested case-control analysis the adjusted matched RR estimates were 2.2 (1.1-4.4) and 2.1 (1.0-4.4) for desogestrel and gestodene users, respectively, compared with users of levonorgestrel. The excess risk for nonfatal VTE associated with the new generation of combined OCs containing low-dose oestrogen and the progestagens desogestrel or gestodene compared with levonorgestrel is estimated to be 16 per 100,000 woman-years.</abstract><cop>London</cop><pub>Lancet</pub><pmid>7500750</pmid><doi>10.1016/S0140-6736(95)91928-7</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0140-6736 |
ispartof | The Lancet (British edition), 1995-12, Vol.346 (8990), p.1589-1593 |
issn | 0140-6736 1474-547X |
language | eng |
recordid | cdi_proquest_journals_199032486 |
source | MEDLINE; EBSCOhost Business Source Complete; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
subjects | Adult Biological and medical sciences Birth control Cardiovascular disease Cardiovascular Diseases - chemically induced Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Case-Control Studies Cohort Studies Contraceptives Contraceptives, Oral, Combined - adverse effects Desogestrel - adverse effects Drug toxicity and drugs side effects treatment Estrogens Ethinyl Estradiol - administration & dosage Female Health risks Humans Incidence Levonorgestrel - adverse effects Medical research Medical sciences Norpregnenes - adverse effects Pharmacology. Drug treatments Progestins - adverse effects Risk Factors Thromboembolism Thromboembolism - chemically induced Thromboembolism - epidemiology Toxicity: cardiovascular system Women |
title | Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T23%3A06%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20of%20idiopathic%20cardiovascular%20death%20and%20nonfatal%20venous%20thromboembolism%20in%20women%20using%20oral%20contraceptives%20with%20differing%20progestagen%20components&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=JICK,%20H&rft.date=1995-12-16&rft.volume=346&rft.issue=8990&rft.spage=1589&rft.epage=1593&rft.pages=1589-1593&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/S0140-6736(95)91928-7&rft_dat=%3Cproquest_pubme%3E8703544%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199032486&rft_id=info:pmid/7500750&rfr_iscdi=true |