Caesarean section and risk of vertical transmission of HIV-1 infection
Summary Indirect evidence suggests that a significant proportion of vertical transmission of HIV infection occurs late in pregnancy or during delivery. Caesarean section, therefore, may protect the fetus from infection. We looked at 1254 HIV-infected mothers and their children and the effects of dif...
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| Veröffentlicht in: | The Lancet (British edition) 1994-06, Vol.343 (8911), p.1464-1467 |
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| creator | Newell, M L Dunn, D T Peckham, C S Ades, A E |
| description | Summary
Indirect evidence suggests that a significant proportion of vertical transmission of HIV infection occurs late in pregnancy or during delivery. Caesarean section, therefore, may protect the fetus from infection.
We looked at 1254 HIV-infected mothers and their children and the effects of different modes of delivery on transmission risk. We also included a detailed assessment of confounding factors associated with transmission risk. Women who had caesarean sections were more advanced in their disease progression which may cause the protective effect of caesarean section to be underestimated. When this and other potential confounding factors were taken into account, caesarean section was estimated to halve the rate of transmission.
This finding is important in the design of studies to evaluate treatments aimed at reducing mother-to-child transmission. |
| doi_str_mv | 10.1016/S0140-6736(94)92582-8 |
| format | Article |
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Indirect evidence suggests that a significant proportion of vertical transmission of HIV infection occurs late in pregnancy or during delivery. Caesarean section, therefore, may protect the fetus from infection.
We looked at 1254 HIV-infected mothers and their children and the effects of different modes of delivery on transmission risk. We also included a detailed assessment of confounding factors associated with transmission risk. Women who had caesarean sections were more advanced in their disease progression which may cause the protective effect of caesarean section to be underestimated. When this and other potential confounding factors were taken into account, caesarean section was estimated to halve the rate of transmission.
This finding is important in the design of studies to evaluate treatments aimed at reducing mother-to-child transmission.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(94)92582-8</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Births ; Cesarean section ; Diseases of mother, fetus and pregnancy ; Gynecology. Andrology. Obstetrics ; Health risk assessment ; HIV ; Human immunodeficiency virus ; Medical research ; Medical sciences ; Pregnancy. Fetus. Placenta</subject><ispartof>The Lancet (British edition), 1994-06, Vol.343 (8911), p.1464-1467</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Jun 11, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-3b42990189df26fe7616551c27f3044019bf6e076eeeef49e72d500afcb7032b3</citedby><cites>FETCH-LOGICAL-c363t-3b42990189df26fe7616551c27f3044019bf6e076eeeef49e72d500afcb7032b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199030775?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4146666$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Newell, M L</creatorcontrib><creatorcontrib>Dunn, D T</creatorcontrib><creatorcontrib>Peckham, C S</creatorcontrib><creatorcontrib>Ades, A E</creatorcontrib><creatorcontrib>The European Collaborative Study</creatorcontrib><title>Caesarean section and risk of vertical transmission of HIV-1 infection</title><title>The Lancet (British edition)</title><description>Summary
Indirect evidence suggests that a significant proportion of vertical transmission of HIV infection occurs late in pregnancy or during delivery. Caesarean section, therefore, may protect the fetus from infection.
We looked at 1254 HIV-infected mothers and their children and the effects of different modes of delivery on transmission risk. We also included a detailed assessment of confounding factors associated with transmission risk. Women who had caesarean sections were more advanced in their disease progression which may cause the protective effect of caesarean section to be underestimated. When this and other potential confounding factors were taken into account, caesarean section was estimated to halve the rate of transmission.
This finding is important in the design of studies to evaluate treatments aimed at reducing mother-to-child transmission.</description><subject>Biological and medical sciences</subject><subject>Births</subject><subject>Cesarean section</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health risk assessment</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pregnancy. Fetus. 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Andrology. Obstetrics</topic><topic>Health risk assessment</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newell, M L</creatorcontrib><creatorcontrib>Dunn, D T</creatorcontrib><creatorcontrib>Peckham, C S</creatorcontrib><creatorcontrib>Ades, A E</creatorcontrib><creatorcontrib>The European Collaborative Study</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newell, M L</au><au>Dunn, D T</au><au>Peckham, C S</au><au>Ades, A E</au><aucorp>The European Collaborative Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caesarean section and risk of vertical transmission of HIV-1 infection</atitle><jtitle>The Lancet (British edition)</jtitle><date>1994-06-11</date><risdate>1994</risdate><volume>343</volume><issue>8911</issue><spage>1464</spage><epage>1467</epage><pages>1464-1467</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary
Indirect evidence suggests that a significant proportion of vertical transmission of HIV infection occurs late in pregnancy or during delivery. Caesarean section, therefore, may protect the fetus from infection.
We looked at 1254 HIV-infected mothers and their children and the effects of different modes of delivery on transmission risk. We also included a detailed assessment of confounding factors associated with transmission risk. Women who had caesarean sections were more advanced in their disease progression which may cause the protective effect of caesarean section to be underestimated. When this and other potential confounding factors were taken into account, caesarean section was estimated to halve the rate of transmission.
This finding is important in the design of studies to evaluate treatments aimed at reducing mother-to-child transmission.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0140-6736(94)92582-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1994-06, Vol.343 (8911), p.1464-1467 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals; Business Source Complete; ProQuest Central UK/Ireland |
| subjects | Biological and medical sciences Births Cesarean section Diseases of mother, fetus and pregnancy Gynecology. Andrology. Obstetrics Health risk assessment HIV Human immunodeficiency virus Medical research Medical sciences Pregnancy. Fetus. Placenta |
| title | Caesarean section and risk of vertical transmission of HIV-1 infection |
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