Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

Summary Background Angiotensin receptor blockers (ARB) and angiotensin converting enzyme (ACE) inhibitors are known to reduce proteinuria. Their combination might be more effective than either treatment alone, but long-term data for comparative changes in renal function are not available. We investi...

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Veröffentlicht in:	The Lancet (British edition) 2008-08, Vol.372 (9638), p.547-553
Hauptverfasser:	Mann, Johannes FE, Prof, Schmieder, Roland E, Prof, McQueen, Matthew, Prof, Dyal, Leanne, MSc, Schumacher, Helmut, MD, Pogue, Janice, PhD, Wang, Xingyu, PhD, Maggioni, Aldo, MD, Budaj, Andrzej, MD, Chaithiraphan, Suphachai, Prof, Dickstein, Kenneth, MD, Keltai, Matyas, Prof, Metsärinne, Kaj, MD, Oto, Ali, Prof, Parkhomenko, Alexander, MD, Piegas, Leopoldo S, MD, Svendsen, Tage L, MD, Teo, Koon K, Prof, Yusuf, Salim, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Aged Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - adverse effects Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Benzimidazoles - therapeutic use Benzoates - administration & dosage Benzoates - adverse effects Benzoates - therapeutic use Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Clinical trials Creatinine - blood Creatinine - urine Diabetes Mellitus - drug therapy Dialysis Disease Double-Blind Method Drug Therapy, Combination Drugs Follow-Up Studies Glomerular Filtration Rate - drug effects Humans Internal Medicine Kidney - drug effects Kidneys Middle Aged Proteinuria - chemically induced Proteinuria - metabolism Ramipril - administration & dosage Ramipril - adverse effects Ramipril - therapeutic use Renal function Risk Studies Urine Vascular diseases
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