Association between tuberculosis and polymorphic NF[kappa]B binding site in the interferon [gamma] gene
Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosi...
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| Veröffentlicht in: | The Lancet (British edition) 2003-05, Vol.361 (9372), p.1871 |
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| creator | Rossouw, Manda Nel, Hendrik J Cooke, Graham S van Helden, Paul D Hoal, Eileen G |
| description | Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A-->T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis. |
| doi_str_mv | 10.1016/S0140-6736(03)13491-5 |
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| subjects | Clinical trials Family studies Genetics Tuberculosis |
| title | Association between tuberculosis and polymorphic NF[kappa]B binding site in the interferon [gamma] gene |
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