Unexpected healing of cutaneous ulcers in a short child
A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapaci...
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| Veröffentlicht in: | The Lancet (British edition) 2001-07, Vol.358 (9277), p.211-212 |
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| creator | Cimaz, Rolando Rusconi, Roberto Fossali, Emilio Careddu, Paolo |
| description | A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue. |
| doi_str_mv | 10.1016/S0140-6736(01)05413-7 |
| format | Article |
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His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(01)05413-7</identifier><identifier>PMID: 11476842</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Blood pressure ; Child ; Crises ; Erythromelalgia - drug therapy ; Erythromelalgia - etiology ; Growth Hormone - therapeutic use ; Hormones ; Human Growth Hormone - deficiency ; Humans ; Leg Ulcer - drug therapy ; Leg Ulcer - etiology ; Legs ; Male ; Medical research ; Medical sciences ; Pain ; Pediatrics ; Pharmacology. 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His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue.</description><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Child</subject><subject>Crises</subject><subject>Erythromelalgia - drug therapy</subject><subject>Erythromelalgia - etiology</subject><subject>Growth Hormone - therapeutic use</subject><subject>Hormones</subject><subject>Human Growth Hormone - deficiency</subject><subject>Humans</subject><subject>Leg Ulcer - drug therapy</subject><subject>Leg Ulcer - etiology</subject><subject>Legs</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pain</subject><subject>Pediatrics</subject><subject>Pharmacology. 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| ispartof | The Lancet (British edition), 2001-07, Vol.358 (9277), p.211-212 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EBSCOhost Business Source Complete |
| subjects | Biological and medical sciences Blood pressure Child Crises Erythromelalgia - drug therapy Erythromelalgia - etiology Growth Hormone - therapeutic use Hormones Human Growth Hormone - deficiency Humans Leg Ulcer - drug therapy Leg Ulcer - etiology Legs Male Medical research Medical sciences Pain Pediatrics Pharmacology. Drug treatments Skin, nail, hair, dermoskeleton Ulcers Wound Healing - drug effects |
| title | Unexpected healing of cutaneous ulcers in a short child |
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