Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

Genetic predisposition to inflammatory bowel disease (IBD) has been shown by epidemiological and linkage studies. Genetic linkage of IBD to chromosome 16 has been previously observed and replicated in independent populations. The recently identified NOD2 gene is a good positional and functional cand...

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Veröffentlicht in:	The Lancet (British edition) 2001-06, Vol.357 (9272), p.1925-1928
Hauptverfasser:	Hampe, Jochen, Cuthbert, Andrew, Croucher, Peter JP, Mirza, Muddassar M, Mascheretti, Silvia, Fisher, Sheila, Frenzel, Henning, King, Kathy, Hasselmeyer, Anja, MacPherson, Andrew JS, Bridger, Stephen, van Deventer, Sander, Forbes, Alastair, Nikolaus, Susanna, Lennard-Jones, John E, Foelsch, Ulrich R, Krawczak, Michael, Lewis, Cathryn, Schreiber, Stefan, Mathew, Christopher G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Bowel disease Carrier Proteins Chromosomes, Human, Pair 16 Colitis, Ulcerative - genetics Crohn Disease - genetics Digestive system England Frameshift Mutation - genetics Gene Frequency - genetics Genes Genetic Predisposition to Disease - genetics Genetics Genotype Genotypes Germany Health risks Humans Intracellular Signaling Peptides and Proteins Investigative techniques, diagnostic techniques (general aspects) Medical sciences Minority & ethnic groups Mutagenesis, Insertional - genetics Mutation NF-kappa B - genetics Nod2 Signaling Adaptor Protein Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype Proteins - genetics
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