EFFECT OF INTRANASAL GLUCAGON ON BLOOD GLUCOSE LEVELS IN HEALTHY SUBJECTS AND HYPOGLYCAEMIC PATIENTS WITH INSULIN-DEPENDENT DIABETES
Glucagon in solution with a surfactant (deoxycholic acid 1% w/v) was administered by intranasal spray to 6 healthy fasting subjects and 6 insulin-dependent diabetics with insulin-induced hypoglycaemia. In the normal subjects, intranasal glucagon increased plasma glucose levels, with a dose-response...
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| Veröffentlicht in: | The Lancet (British edition) 1988-06, Vol.331 (8599), p.1364-1366 |
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| container_issue | 8599 |
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| container_title | The Lancet (British edition) |
| container_volume | 331 |
| creator | Freychet, L. Desplanque, N. Zirinis, P. Rizkalla, S.W. Basdevant, A. Tchobroutsky, G. Slama, G. |
| description | Glucagon in solution with a surfactant (deoxycholic acid 1% w/v) was administered by intranasal spray to 6 healthy fasting subjects and 6 insulin-dependent diabetics with insulin-induced hypoglycaemia. In the normal subjects, intranasal glucagon increased plasma glucose levels, with a dose-response effect. In the diabetic patients, plasma glucose levels showed a mean increase of 100% above nadir values in approximately 26 min in response to 7·5 mg intranasal glucagon; hypoglycaemic symptoms were relieved within about 7 min. These results suggest that intranasal glucagon is effective and may represent an alternative to parenteral glucagon or glucose or to oral sugar as the first-line treatment of hypoglycaemic episodes in insulin-dependent diabetics. |
| doi_str_mv | 10.1016/S0140-6736(88)92181-2 |
| format | Article |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1988-06, Vol.331 (8599), p.1364-1366 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Diabetes Dose-response effects Drugs Insulin Medical research Sugar |
| title | EFFECT OF INTRANASAL GLUCAGON ON BLOOD GLUCOSE LEVELS IN HEALTHY SUBJECTS AND HYPOGLYCAEMIC PATIENTS WITH INSULIN-DEPENDENT DIABETES |
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