RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY
To examine the potential role of fish oil supplementation in the prevention of restenosis after coronary angioplasty (PTCA), a randomised double-blind trial was conducted in 204 patients. The treatment group received 6 g/day of n-3 fatty acids, beginning 5·4 (SD 3·2) days before PTCA, and continuing...
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| Veröffentlicht in: | The Lancet (British edition) 1989-07, Vol.334 (8656), p.177-181 |
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| container_issue | 8656 |
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| container_title | The Lancet (British edition) |
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| creator | Reis, GreggJ Sipperly, MaryEllen Mccabe, CarolynH Sacks, FrankM Boucher, TheresaM Silverman, DavidI Baim, DonaldS Grossman, William Pasternak, RichardC |
| description | To examine the potential role of fish oil supplementation in the prevention of restenosis after coronary angioplasty (PTCA), a randomised double-blind trial was conducted in 204 patients. The treatment group received 6 g/day of n-3 fatty acids, beginning 5·4 (SD 3·2) days before PTCA, and continuing for 6 months; the control group received olive oil placebo. Compliance was assessed by pill count and plasma levels of eicosapentaenoic acid (EPA). Restenosis was identified by symptoms and exercise testing and confirmed by angiography. PTCA was successful in 186 patients (93%). The incidence of angiographic restenosis was 34% in the fish oil group and 23% in the control group (relative risk 1·7, 95% CI 0·9-3·4). The lack of benefit of fish oil was not influenced by length of pretreatment, compliance with study medication, or the concentrations of plasma EPA achieved. |
| doi_str_mv | 10.1016/S0140-6736(89)90370-X |
| format | Article |
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The treatment group received 6 g/day of n-3 fatty acids, beginning 5·4 (SD 3·2) days before PTCA, and continuing for 6 months; the control group received olive oil placebo. Compliance was assessed by pill count and plasma levels of eicosapentaenoic acid (EPA). Restenosis was identified by symptoms and exercise testing and confirmed by angiography. PTCA was successful in 186 patients (93%). The incidence of angiographic restenosis was 34% in the fish oil group and 23% in the control group (relative risk 1·7, 95% CI 0·9-3·4). 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The lack of benefit of fish oil was not influenced by length of pretreatment, compliance with study medication, or the concentrations of plasma EPA achieved.</description><subject>Cardiovascular disease</subject><subject>Fish</subject><subject>Fish oils</subject><subject>Medical research</subject><subject>Oils & fats</subject><subject>Olive oil</subject><subject>Prevention</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqFkM1Og0AUhSdGE2v1EUwmrnSBzsD8wMqQFtpJkGkGNO1qQochodGi0Bp9e6E1bt3cu7jnnJvzAXCN0T1GmD1kCBPkMO6xWz-4C5DHkbM8ASNMOHEo4ctTMPqTnIOLrtsghAhDdARyFaZT-SSyaApzJcIEyhjGIptDKRIYSwUXKnqJ0lzIdDipKMujVGYig2GcRwpOpJJpqFYwTGdCLpIwy1eX4KwqXjt79bvH4DmO8sncSeRMTMLEMW7Avpx1ZUpEeIH9snArEjDjV5hzQnnZT4-uA8SQ61FmMfGMoQXyrDGElRxb7LnYG4ObY-5723zsbbfTm2bfbvuXGgd-QAnzBxE9ikzbdF1rK_3e1m9F-60x0gM_feCnBzjaD_SBn172vsejz_YNPmvb6s7UdmtsWbfW7HTZ1P8k_ACjN29X</recordid><startdate>19890722</startdate><enddate>19890722</enddate><creator>Reis, GreggJ</creator><creator>Sipperly, MaryEllen</creator><creator>Mccabe, CarolynH</creator><creator>Sacks, FrankM</creator><creator>Boucher, TheresaM</creator><creator>Silverman, DavidI</creator><creator>Baim, DonaldS</creator><creator>Grossman, William</creator><creator>Pasternak, RichardC</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19890722</creationdate><title>RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY</title><author>Reis, GreggJ ; Sipperly, MaryEllen ; Mccabe, CarolynH ; Sacks, FrankM ; Boucher, TheresaM ; Silverman, DavidI ; Baim, DonaldS ; Grossman, William ; Pasternak, RichardC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296x-bfcd047a18da2f496c8f177457d77435b90602356e143cc5a03ecc46d71e13213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Cardiovascular disease</topic><topic>Fish</topic><topic>Fish oils</topic><topic>Medical research</topic><topic>Oils & fats</topic><topic>Olive oil</topic><topic>Prevention</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reis, GreggJ</creatorcontrib><creatorcontrib>Sipperly, MaryEllen</creatorcontrib><creatorcontrib>Mccabe, CarolynH</creatorcontrib><creatorcontrib>Sacks, FrankM</creatorcontrib><creatorcontrib>Boucher, TheresaM</creatorcontrib><creatorcontrib>Silverman, DavidI</creatorcontrib><creatorcontrib>Baim, DonaldS</creatorcontrib><creatorcontrib>Grossman, William</creatorcontrib><creatorcontrib>Pasternak, RichardC</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reis, GreggJ</au><au>Sipperly, MaryEllen</au><au>Mccabe, CarolynH</au><au>Sacks, FrankM</au><au>Boucher, TheresaM</au><au>Silverman, DavidI</au><au>Baim, DonaldS</au><au>Grossman, William</au><au>Pasternak, RichardC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY</atitle><jtitle>The Lancet (British edition)</jtitle><date>1989-07-22</date><risdate>1989</risdate><volume>334</volume><issue>8656</issue><spage>177</spage><epage>181</epage><pages>177-181</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>To examine the potential role of fish oil supplementation in the prevention of restenosis after coronary angioplasty (PTCA), a randomised double-blind trial was conducted in 204 patients. 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| fulltext | fulltext |
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| ispartof | The Lancet (British edition), 1989-07, Vol.334 (8656), p.177-181 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Cardiovascular disease Fish Fish oils Medical research Oils & fats Olive oil Prevention |
| title | RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY |
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