Comparison of Targeted Mass Spectrometry Techniques with an Immunoassay: A Case Study for HSP90[alpha]

Purpose The objective of this study is to better understand factors governing the variability and sensitivity in SRM and PRM, compared to immunoassay. Experimental design A 2D-LC-MS/MS-based SRM and PRM assay is developed for quantitative measurements of HSP90[alpha] in serum. Forty-three control se...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proteomics. Clinical applications 2018-01, Vol.12 (1)
Hauptverfasser:	Guzel, Coskun, Govorukhina, Natalia I, Stingl, Christoph, Dekker, Lennard J M, Boichenko, Alexander, van der Zee, Ate G J, Bischoff, Rainer PH, Luider, Theo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Binders Case studies Cation exchange Cation exchanging Correlation analysis Enzyme-linked immunosorbent assay Experimental design Fractionation High resolution Hsp90 protein Immunoassay Immunoassays Linearity Mass spectrometry Mass spectroscopy Mathematical analysis Quadrupoles Reproducibility Sensitivity Trypsin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!