Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan
Summary objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined. patients and measurements We examined lipid levels in a group of untreated severely GHD patient...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2002-07, Vol.57 (1), p.89-95 |
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| creator | Gleeson, Helena K. Souza, Anita H. O. Gill, Matthew S. Wieringa, Gilbert E. De A. Barretto, Elenilde S. Barretto‐Filho, J. A. S. Shalet, Stephen M. Aguiar‐Oliveira, Manuel H. Clayton, Peter E. |
| description | Summary
objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined.
patients and measurements We examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in North‐east Brazil. Lipid profiles in 15 GHD subjects [eight children and adolescents (one male), age (median [range]) 13·2 (5·4–19·9) years; seven adults (one male), age 47 (33–66) years] were compared with those in 29 indigenous controls from the same extended kindred [17 children and adolescents (six male), age 10·2 (5·3–18·4) years; 12 adults (eight male), age 54·5 (33–80) years]. All GHD subjects had a peak GH response of < 0·5 ng/ml in response to an insulin tolerance test and extremely reduced IGF‐1 levels (median 5·5 ng/ml). Data were compared between cohorts and with an age‐ and sex‐matched white American reference population.
results Abnormalities were confined to plasma total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels. More GHD children had levels of plasma TC and LDL‐C above the 95th percentile for our reference population (3/8 and 4/7, respectively) compared to controls (0/17 and 1/15, respectively) (P |
| doi_str_mv | 10.1046/j.1365-2265.2002.01568.x |
| format | Article |
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objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined.
patients and measurements We examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in North‐east Brazil. Lipid profiles in 15 GHD subjects [eight children and adolescents (one male), age (median [range]) 13·2 (5·4–19·9) years; seven adults (one male), age 47 (33–66) years] were compared with those in 29 indigenous controls from the same extended kindred [17 children and adolescents (six male), age 10·2 (5·3–18·4) years; 12 adults (eight male), age 54·5 (33–80) years]. All GHD subjects had a peak GH response of < 0·5 ng/ml in response to an insulin tolerance test and extremely reduced IGF‐1 levels (median 5·5 ng/ml). Data were compared between cohorts and with an age‐ and sex‐matched white American reference population.
results Abnormalities were confined to plasma total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels. More GHD children had levels of plasma TC and LDL‐C above the 95th percentile for our reference population (3/8 and 4/7, respectively) compared to controls (0/17 and 1/15, respectively) (P < 0·05). In the adults, median TC and LDL‐C levels were higher in the GHD than controls (P < 0·05) (6·3 vs. 4·1 mmol/l; 4·4 vs. 2·7 mmol/l, respectively). Median Z‐scores, calculated using values from the reference population, were not different between GHD children and adults for both TC (+0·8 vs.+0·4) and LDL‐C (+1·4 vs.+0·7).
conclusions The lipid profile in children as well as in adults with very severe GHD is adversely modified. There would appear to be no significant worsening of the lipid abnormality with duration of GHD or achievement of adulthood.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1046/j.1365-2265.2002.01568.x</identifier><identifier>PMID: 12100075</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Brazil ; Case-Control Studies ; Child ; Child, Preschool ; Cholesterol - blood ; Cholesterol, HDL - blood ; Disease Progression ; Endocrinopathies ; Female ; Growth Hormone - deficiency ; Humans ; Hypothalamus. Hypophysis. Epiphysis (diseases) ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Mutation ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pituitary Diseases - blood ; Pituitary Diseases - genetics ; Receptors, Somatotropin - genetics ; Statistics, Nonparametric ; Triglycerides - blood ; Tropical medicine</subject><ispartof>Clinical endocrinology (Oxford), 2002-07, Vol.57 (1), p.89-95</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jul 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3918-6ff78401ed06e86be1f3738d7de622a5a29c3a6f67b77bf28dd9889d9426254c3</citedby><cites>FETCH-LOGICAL-c3918-6ff78401ed06e86be1f3738d7de622a5a29c3a6f67b77bf28dd9889d9426254c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2265.2002.01568.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13805174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12100075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gleeson, Helena K.</creatorcontrib><creatorcontrib>Souza, Anita H. O.</creatorcontrib><creatorcontrib>Gill, Matthew S.</creatorcontrib><creatorcontrib>Wieringa, Gilbert E.</creatorcontrib><creatorcontrib>De A. Barretto, Elenilde S.</creatorcontrib><creatorcontrib>Barretto‐Filho, J. A. S.</creatorcontrib><creatorcontrib>Shalet, Stephen M.</creatorcontrib><creatorcontrib>Aguiar‐Oliveira, Manuel H.</creatorcontrib><creatorcontrib>Clayton, Peter E.</creatorcontrib><title>Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined.
patients and measurements We examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in North‐east Brazil. Lipid profiles in 15 GHD subjects [eight children and adolescents (one male), age (median [range]) 13·2 (5·4–19·9) years; seven adults (one male), age 47 (33–66) years] were compared with those in 29 indigenous controls from the same extended kindred [17 children and adolescents (six male), age 10·2 (5·3–18·4) years; 12 adults (eight male), age 54·5 (33–80) years]. All GHD subjects had a peak GH response of < 0·5 ng/ml in response to an insulin tolerance test and extremely reduced IGF‐1 levels (median 5·5 ng/ml). Data were compared between cohorts and with an age‐ and sex‐matched white American reference population.
results Abnormalities were confined to plasma total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels. More GHD children had levels of plasma TC and LDL‐C above the 95th percentile for our reference population (3/8 and 4/7, respectively) compared to controls (0/17 and 1/15, respectively) (P < 0·05). In the adults, median TC and LDL‐C levels were higher in the GHD than controls (P < 0·05) (6·3 vs. 4·1 mmol/l; 4·4 vs. 2·7 mmol/l, respectively). Median Z‐scores, calculated using values from the reference population, were not different between GHD children and adults for both TC (+0·8 vs.+0·4) and LDL‐C (+1·4 vs.+0·7).
conclusions The lipid profile in children as well as in adults with very severe GHD is adversely modified. There would appear to be no significant worsening of the lipid abnormality with duration of GHD or achievement of adulthood.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Disease Progression</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Growth Hormone - deficiency</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis (diseases)</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Pituitary Diseases - blood</subject><subject>Pituitary Diseases - genetics</subject><subject>Receptors, Somatotropin - genetics</subject><subject>Statistics, Nonparametric</subject><subject>Triglycerides - blood</subject><subject>Tropical medicine</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEuP0zAQgC0EYsvCX0AWEscEPxLbOXBA1fKQKrjA2XLtcesqtYudsNt_j7Ot2CunmdF8M_Z8CGFKWko68eHQUi76hjHRt4wQ1hLaC9U-PEOrf43naEU4IQ0RortBr0o5EEJ6ReRLdEMZrYXsVwg24RQcPuXkwwgFh4jnOGUwEzhc4A9kwDbFHcQwmRGHksbH1i6n-2mP9ykfUwTswAcbINoznvY5zbt9jYDH4KGcTHyNXngzFnhzjbfo1-e7n-uvzebHl2_rT5vG8oGqRngvVUcoOCJAiS1QzyVXTjoQjJnesMFyI7yQWym3ninnBqUGN3RMsL6z_Ba9u-yt9_yeoUz6kOYc65OaDkoqVe-vkLpANqdSMnh9yuFo8llTohe9-qAXi3qxqBe9-lGvfqijb6_75-0R3NPg1WcF3l8BU6wZfTbRhvLEcUV6KrvKfbxw99X6-b8_oNd335eM_wUy2JbJ</recordid><startdate>200207</startdate><enddate>200207</enddate><creator>Gleeson, Helena K.</creator><creator>Souza, Anita H. O.</creator><creator>Gill, Matthew S.</creator><creator>Wieringa, Gilbert E.</creator><creator>De A. Barretto, Elenilde S.</creator><creator>Barretto‐Filho, J. A. S.</creator><creator>Shalet, Stephen M.</creator><creator>Aguiar‐Oliveira, Manuel H.</creator><creator>Clayton, Peter E.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>200207</creationdate><title>Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan</title><author>Gleeson, Helena K. ; Souza, Anita H. O. ; Gill, Matthew S. ; Wieringa, Gilbert E. ; De A. Barretto, Elenilde S. ; Barretto‐Filho, J. A. S. ; Shalet, Stephen M. ; Aguiar‐Oliveira, Manuel H. ; Clayton, Peter E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3918-6ff78401ed06e86be1f3738d7de622a5a29c3a6f67b77bf28dd9889d9426254c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Disease Progression</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Growth Hormone - deficiency</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis (diseases)</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Pituitary Diseases - blood</topic><topic>Pituitary Diseases - genetics</topic><topic>Receptors, Somatotropin - genetics</topic><topic>Statistics, Nonparametric</topic><topic>Triglycerides - blood</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gleeson, Helena K.</creatorcontrib><creatorcontrib>Souza, Anita H. O.</creatorcontrib><creatorcontrib>Gill, Matthew S.</creatorcontrib><creatorcontrib>Wieringa, Gilbert E.</creatorcontrib><creatorcontrib>De A. Barretto, Elenilde S.</creatorcontrib><creatorcontrib>Barretto‐Filho, J. A. S.</creatorcontrib><creatorcontrib>Shalet, Stephen M.</creatorcontrib><creatorcontrib>Aguiar‐Oliveira, Manuel H.</creatorcontrib><creatorcontrib>Clayton, Peter E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gleeson, Helena K.</au><au>Souza, Anita H. O.</au><au>Gill, Matthew S.</au><au>Wieringa, Gilbert E.</au><au>De A. Barretto, Elenilde S.</au><au>Barretto‐Filho, J. A. S.</au><au>Shalet, Stephen M.</au><au>Aguiar‐Oliveira, Manuel H.</au><au>Clayton, Peter E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2002-07</date><risdate>2002</risdate><volume>57</volume><issue>1</issue><spage>89</spage><epage>95</epage><pages>89-95</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined.
patients and measurements We examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in North‐east Brazil. Lipid profiles in 15 GHD subjects [eight children and adolescents (one male), age (median [range]) 13·2 (5·4–19·9) years; seven adults (one male), age 47 (33–66) years] were compared with those in 29 indigenous controls from the same extended kindred [17 children and adolescents (six male), age 10·2 (5·3–18·4) years; 12 adults (eight male), age 54·5 (33–80) years]. All GHD subjects had a peak GH response of < 0·5 ng/ml in response to an insulin tolerance test and extremely reduced IGF‐1 levels (median 5·5 ng/ml). Data were compared between cohorts and with an age‐ and sex‐matched white American reference population.
results Abnormalities were confined to plasma total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels. More GHD children had levels of plasma TC and LDL‐C above the 95th percentile for our reference population (3/8 and 4/7, respectively) compared to controls (0/17 and 1/15, respectively) (P < 0·05). In the adults, median TC and LDL‐C levels were higher in the GHD than controls (P < 0·05) (6·3 vs. 4·1 mmol/l; 4·4 vs. 2·7 mmol/l, respectively). Median Z‐scores, calculated using values from the reference population, were not different between GHD children and adults for both TC (+0·8 vs.+0·4) and LDL‐C (+1·4 vs.+0·7).
conclusions The lipid profile in children as well as in adults with very severe GHD is adversely modified. There would appear to be no significant worsening of the lipid abnormality with duration of GHD or achievement of adulthood.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12100075</pmid><doi>10.1046/j.1365-2265.2002.01568.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Brazil Case-Control Studies Child Child, Preschool Cholesterol - blood Cholesterol, HDL - blood Disease Progression Endocrinopathies Female Growth Hormone - deficiency Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Lipids - blood Male Medical sciences Middle Aged Mutation Non tumoral diseases. Target tissue resistance. Benign neoplasms Pituitary Diseases - blood Pituitary Diseases - genetics Receptors, Somatotropin - genetics Statistics, Nonparametric Triglycerides - blood Tropical medicine |
| title | Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan |
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