Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity?

OBJECTIVE In order to explore the mechanism of obesity in long‐term survivors of childhood leukaemia, fat mass, lean body mass and serum leptin were assessed in a cohort of 32 (17 males) adults who had received cranial irradiation (XRT) in childhood as part of their treatment for acute lymphoblastic...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 1999-02, Vol.50 (2), p.163-169
Hauptverfasser:	BRENNAN, B. M. D, RAHIM, A, BLUM, W. F, ADAMS, J. A, EDEN, O. B, SHALET, S. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis of Variance Biological and medical sciences Body Composition Case-Control Studies Child Endocrinopathies Female Follow-Up Studies Growth Hormone - deficiency Humans Hypothalamus - radiation effects Hypothalamus. Hypophysis. Epiphysis (diseases) Leptin Linear Models Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Obesity - blood Obesity - etiology Pituitary Irradiation - adverse effects Precursor Cell Lymphoblastic Leukemia-Lymphoma - radiotherapy Proteins - analysis Statistics, Nonparametric
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