Synthesis of Chiral Acyclic Pyrimidine Nucleosides with a Sulfur‐Containing Side Chain via Enantioselective Tandem Conjugate Addition/Protonation

A direct route to chiral pyrimidine acyclic nucleoside analogues with a sulfur‐containing side chain is reported via enantioselective tandem conjugated addition‐protonation reactions of thioacetic acid to α‐pyrimidine substituted acrylates. In the presence of a quinine‐derived thiourea catalyst, div...

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Veröffentlicht in:	Asian journal of organic chemistry 2018-01, Vol.7 (1), p.128-132
Hauptverfasser:	Li, Jian‐Ping, Tuo, Hao‐Ran, Xie, Ming‐Sheng, Kang, Bo, Qu, Gui‐Rong, Guo, Hai‐Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates Antiretroviral drugs Cascade chemical reactions Chains Crystal structure enantioselectivity Nucleosides Organic chemistry organocatalysis organosulfur compounds Protonation pyrimidines Sulfur
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