Chairside molecular imaging of aberrant glycosylation in subjects with suspicious oral lesions using fluorescently labeled wheat germ agglutinin

Background Aberrant sialylation is accepted as a carcinogenic biomarker. In previous work, fluorescently labeled wheat germ agglutinin (WGA) distinguished between cancerous and normal oral biopsies. The purpose of this study was to investigate WGA‐fluorescein isothiocyanate (FITC) as a point‐of‐care...

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Veröffentlicht in:	Head & neck 2018-02, Vol.40 (2), p.292-301
Hauptverfasser:	Baeten, John, Johnson, Alexander, Sunny, Sumsum, Suresh, Amritha, Birur, Praveen, Uma, K, Kademani, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	aberrant glycosylation Adolescent Adult Aged Carcinogenesis Diagnosis, Differential Female Fluorescein isothiocyanate Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - metabolism Glycosylation Head and neck Humans Localization Male Middle Aged molecular imaging Molecular Imaging - methods Mouth Diseases - diagnostic imaging Mouth Diseases - metabolism Mouth Diseases - pathology Mouth Mucosa - diagnostic imaging Mouth Mucosa - metabolism Mouth Mucosa - pathology Mouth Neoplasms - diagnosis Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mucosa N-Acetylneuraminic Acid - metabolism Oral cancer sialic acid Staining and Labeling - methods Wheat germ Wheat germ agglutinin Wheat Germ Agglutinins - metabolism wheat germ agglutinin‐fluorescein isothiocyanate (WGA‐FITC) Young Adult
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