Membrane‐bound iron contributes to oxidative damage of β‐thalassaemia intermedia erythrocytes
Iron‐dependent oxidative reactions in β‐thalassaemic erythrocyte membranes are involved in premature cell removal and anaemia. We studied 22 β‐thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether t...
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| Veröffentlicht in: | British journal of haematology 2001-01, Vol.112 (1), p.48-50 |
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| container_title | British journal of haematology |
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| creator | Tavazzi, Dario Duca, Lorena Graziadei, Giovanna Comino, Alessia Fiorelli, Gemino Cappellini, Maria Domenica |
| description | Iron‐dependent oxidative reactions in β‐thalassaemic erythrocyte membranes are involved in premature cell removal and anaemia. We studied 22 β‐thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described in vitro have indicators in circulating erythrocytes. Serum non‐transferrin‐bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane‐bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non‐transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron. |
| doi_str_mv | 10.1046/j.1365-2141.2001.02482.x |
| format | Article |
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We studied 22 β‐thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described in vitro have indicators in circulating erythrocytes. Serum non‐transferrin‐bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane‐bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non‐transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2001.02482.x</identifier><identifier>PMID: 11167782</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Anemias. Hemoglobinopathies ; beta-Thalassemia - metabolism ; beta-Thalassemia - pathology ; beta-Thalassemia - surgery ; Biological and medical sciences ; Case-Control Studies ; Cell Death ; Diseases of red blood cells ; erythrocyte membrane ; Erythrocyte Membrane - metabolism ; Erythrocytes - metabolism ; Erythrocytes - pathology ; Female ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; iron ; Iron - metabolism ; Male ; Medical sciences ; Oxidative Stress ; Splenectomy ; Statistics, Nonparametric ; thalassaemia</subject><ispartof>British journal of haematology, 2001-01, Vol.112 (1), p.48-50</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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We studied 22 β‐thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described in vitro have indicators in circulating erythrocytes. Serum non‐transferrin‐bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane‐bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non‐transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron.</description><subject>Adult</subject><subject>Anemias. Hemoglobinopathies</subject><subject>beta-Thalassemia - metabolism</subject><subject>beta-Thalassemia - pathology</subject><subject>beta-Thalassemia - surgery</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cell Death</subject><subject>Diseases of red blood cells</subject><subject>erythrocyte membrane</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocytes - metabolism</subject><subject>Erythrocytes - pathology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>iron</subject><subject>Iron - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidative Stress</subject><subject>Splenectomy</subject><subject>Statistics, Nonparametric</subject><subject>thalassaemia</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9O3DAUh60KVAbaKyCrrJM-OxnbWXQBqIVWoG5gbTnOC3g0icFOYGbXI_QsHIRDcJI6nRFsWflJ_n7vz0cIZZAzKMXXRc4KMc84K1nOAVgOvFQ8X30gs9ePHTIDAJmlgNoj-zEuEljAnH0ke4wxIaXiM1JfYlcH0-PLn7-1H_uGuuB7an0_BFePA0Y6eOpXrjGDe0DamM7cIPUtfX5KkeHWLE2MBjtnqOsHDB02qcSwHm6Dt-vU4BPZbc0y4ufte0Cuf3y_Oj3PLn6f_Tw9vshsKYFnEtN2yEoruJSGl4hFXZi2ECBNBY20AAIqDlzxlkODFauVLCuurBBlYZrigHzZ9L0L_n7EOOiFH0OfRmpWKTGvBFcJUhvIBh9jwFbfBdeZsNYM9ORWL_SkUE8K9eRW_3erVyl6uO0_1unKt-BWZgKOtoCJ1izbpNW6-MpVcxBs2uDbhnp0S1y_e7w--XU-VcU_9TiW6w</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Tavazzi, Dario</creator><creator>Duca, Lorena</creator><creator>Graziadei, Giovanna</creator><creator>Comino, Alessia</creator><creator>Fiorelli, Gemino</creator><creator>Cappellini, Maria Domenica</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200101</creationdate><title>Membrane‐bound iron contributes to oxidative damage of β‐thalassaemia intermedia erythrocytes</title><author>Tavazzi, Dario ; Duca, Lorena ; Graziadei, Giovanna ; Comino, Alessia ; Fiorelli, Gemino ; Cappellini, Maria Domenica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4702-7e130e14c6277a24ee3b3af3607a90d7c0060920282f20de91b874928c6643ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Anemias. Hemoglobinopathies</topic><topic>beta-Thalassemia - metabolism</topic><topic>beta-Thalassemia - pathology</topic><topic>beta-Thalassemia - surgery</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cell Death</topic><topic>Diseases of red blood cells</topic><topic>erythrocyte membrane</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocytes - metabolism</topic><topic>Erythrocytes - pathology</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>iron</topic><topic>Iron - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidative Stress</topic><topic>Splenectomy</topic><topic>Statistics, Nonparametric</topic><topic>thalassaemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavazzi, Dario</creatorcontrib><creatorcontrib>Duca, Lorena</creatorcontrib><creatorcontrib>Graziadei, Giovanna</creatorcontrib><creatorcontrib>Comino, Alessia</creatorcontrib><creatorcontrib>Fiorelli, Gemino</creatorcontrib><creatorcontrib>Cappellini, Maria Domenica</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavazzi, Dario</au><au>Duca, Lorena</au><au>Graziadei, Giovanna</au><au>Comino, Alessia</au><au>Fiorelli, Gemino</au><au>Cappellini, Maria Domenica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Membrane‐bound iron contributes to oxidative damage of β‐thalassaemia intermedia erythrocytes</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2001-01</date><risdate>2001</risdate><volume>112</volume><issue>1</issue><spage>48</spage><epage>50</epage><pages>48-50</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Iron‐dependent oxidative reactions in β‐thalassaemic erythrocyte membranes are involved in premature cell removal and anaemia. We studied 22 β‐thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described in vitro have indicators in circulating erythrocytes. Serum non‐transferrin‐bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane‐bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non‐transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11167782</pmid><doi>10.1046/j.1365-2141.2001.02482.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anemias. Hemoglobinopathies beta-Thalassemia - metabolism beta-Thalassemia - pathology beta-Thalassemia - surgery Biological and medical sciences Case-Control Studies Cell Death Diseases of red blood cells erythrocyte membrane Erythrocyte Membrane - metabolism Erythrocytes - metabolism Erythrocytes - pathology Female Hematologic and hematopoietic diseases Hematology Humans iron Iron - metabolism Male Medical sciences Oxidative Stress Splenectomy Statistics, Nonparametric thalassaemia |
| title | Membrane‐bound iron contributes to oxidative damage of β‐thalassaemia intermedia erythrocytes |
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