BCR‐ABL influences the antileukaemic efficacy of alkylphosphocholines

We have compared the antileukaemic efficacy of a series of new i.v. injectable alkylphosphocholines (APC) with their clinically used congeners miltefosine and perifosine. The test system consisted of four leukaemic cell lines carrying the bcr‐abl rearrangement (K‐562, LAMA‐84, CML‐T1 and BV‐173) and...

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Veröffentlicht in:	British journal of haematology 1999-11, Vol.107 (2), p.365-374
Hauptverfasser:	Konstantinov, Spiro M., Eibl, Hansjörg, Berger, Martin R.
Format:	Artikel
Sprache:	eng
Schlagworte:	alkylphosphocholines Antineoplastic agents antisense oligonucleotides apoptosis Apoptosis - genetics bcr‐abl Biological and medical sciences Cell Adhesion - drug effects Cell Survival cell‐free system Dose-Response Relationship, Drug Fusion Proteins, bcr-abl - biosynthesis Fusion Proteins, bcr-abl - genetics General aspects Hematology HL-60 Cells Humans Medical sciences Molecular Structure Pharmacology. Drug treatments Phosphorylcholine - analogs & derivatives Phosphorylcholine - toxicity Structure-Activity Relationship Tumor Cells, Cultured
Online-Zugang:	Volltext
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