Binary adduct formation of desipramine with dicarboxylic acids

Binary adduct formation of desipramine with dicarboxylic acids

This paper presents the results obtained in a screening study for binary adduct formation of desipramine with three dicarboxylic acids-namely succinic, malonic and glutaric acids. Adduct formation is important because most tricyclic antidepressants show limited water solubility as free bases. Three...

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Veröffentlicht in:Journal of thermal analysis and calorimetry 2018-01, Vol.131 (1), p.167-173
Hauptverfasser: Ledeti, Adriana, Vlase, Gabriela, Vlase, Titus, Circioban, Denisa, Dehelean, Cristina, Ledeti, Ionut, Suta, Lenuta-Maria
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Sprache:eng
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Adducts
Analysis
Antidepressants
Dicarboxylic acids
Ethanol
Medical schools
Thermal analysis
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container_end_page 173
container_issue 1
container_start_page 167
container_title Journal of thermal analysis and calorimetry
container_volume 131
creator Ledeti, Adriana
Vlase, Gabriela
Vlase, Titus
Circioban, Denisa
Dehelean, Cristina
Ledeti, Ionut
Suta, Lenuta-Maria
description This paper presents the results obtained in a screening study for binary adduct formation of desipramine with three dicarboxylic acids-namely succinic, malonic and glutaric acids. Adduct formation is important because most tricyclic antidepressants show limited water solubility as free bases. Three binary adducts were prepared using a wet kneading method in non-homogenous media in presence of ethanol. Investigations of the solid state (ATR-FTIR, PXRD) and thermal analysis (TG/DTG/HF) were used for characterization of the prepared samples. The corroboration of data from employed instrumental techniques suggests that binary adducts in molar ratio 1:1 were obtained under the used experimental conditions.
doi_str_mv 10.1007/s10973-016-5967-8
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subjects Adducts
Analysis
Antidepressants
Dicarboxylic acids
Ethanol
Medical schools
Thermal analysis
title Binary adduct formation of desipramine with dicarboxylic acids
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