Cigarette smoke extract and isoprene resulted in the induction of apoptosis and autophagy in human placenta choriocarcinoma JEG‐3 cells

In this study, the effects of cigarette smoke (CS) on the induction of apoptosis via reactive oxygen species (ROS) production and endoplasmic reticulum stress (ER stress) of JEG‐3 human choriocarcinoma cells were examined to confirm the relationship between CS and placenta development. Upon TUNEL as...

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Veröffentlicht in:	Environmental toxicology 2018-02, Vol.33 (2), p.178-190
Hauptverfasser:	Lee, Hae‐Miru, Choi, Kyung‐Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Apoptosis Apoptosis - drug effects Assaying Autophagy Autophagy - drug effects BAX protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Butadienes - toxicity CCAAT/enhancer-binding protein cell cycle Cell death Cell Line, Tumor Cells Choriocarcinoma Choriocarcinoma - metabolism Choriocarcinoma - pathology Cigarette smoke Cyclin D1 Cyclin D1 - metabolism Cyclin E - metabolism EMT Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Female GTP-binding protein Hemiterpenes - toxicity Homology Humans Isoprene Kelch-Like ECH-Associated Protein 1 - metabolism Markers NF-E2-Related Factor 2 - metabolism Nicotiana - chemistry Nicotiana - metabolism Oncogene Proteins - metabolism p53 Protein Pentanes - toxicity Phagocytosis Placenta placenta choriocarcinoma Pregnancy Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Sequestosome-1 Protein - metabolism Smoke Smoke - adverse effects Transcription Factor CHOP - metabolism Tumor Suppressor Protein p53 - metabolism Uterine Neoplasms - metabolism Uterine Neoplasms - pathology
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