Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor

Interleukin‐6 (IL‐6) is the major growth factor for human myeloma cells, exerting its effect through the IL‐6 receptor (IL‐6R). A soluble form of IL‐6R (sIL‐6R) has been identified, which increases the sensitivity of myeloma cells to IL‐6. In patients with multiple myeloma (MM), serum concentrations...

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Veröffentlicht in:	British journal of haematology 1998-06, Vol.101 (4), p.694-702
Hauptverfasser:	Hargreaves, Philip G., Wang, Fengfei, Antcliff, Jennifer, Murphy, Gillian, Lawry, John, Russell, R. Graham G., Croucher, Peter I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bone Marrow Cells - metabolism Dose-Response Relationship, Drug Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Medical sciences metalloproteinase multiple myeloma Multiple Myeloma - metabolism Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Protease Inhibitors - pharmacology Receptors, Interleukin-6 - antagonists & inhibitors shedding soluble interleukin‐6 receptor Tetradecanoylphorbol Acetate - pharmacology Thiophenes - pharmacology Tissue Inhibitor of Metalloproteinase-3 - pharmacology tissue inhibitor of metalloproteinase‐3 Tumor Cells, Cultured
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